(Q40037116)

16 September 2017

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells (English)

1 reference

16 September 2017

1 reference

1 reference

Ruth Rott

1

1 reference

16 September 2017

Raymonde Szargel

2

1 reference

16 September 2017

Joseph Haskin

3

1 reference

16 September 2017

Vered Shani

4

1 reference

16 September 2017

Alla Shainskaya

5

1 reference

16 September 2017

Irena Manov

6

1 reference

16 September 2017

Esti Liani

7

1 reference

16 September 2017

Eyal Avraham

8

1 reference

16 September 2017

Simone Engelender

9

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16 September 2017

language of work or name

English

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publication date

10 December 2007

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

6

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16 September 2017

3316-3328

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Molecular pathophysiology of Parkinson's disease

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Genetics of Parkinson's disease and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

The ubiquitin pathway in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Parkin accumulation in aggresomes due to proteasome impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ubiquitination of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Delayed extraction improves specificity in database searches by matrix-assisted laser desorption/ionization peptide maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Matrix-assisted laser desorption/ionization mass spectrometric peptide mapping of the neural cell adhesion protein neurolin purified by sodium dodecyl sulfate polyacrylamide gel electrophoresis or acidic precipitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Regulation of ubiquitin-binding proteins by monoubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Cellular polyamines promote the aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Ubiquitin-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704809200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704809200

1 reference

16 September 2017

1 reference