(Q52678048)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17376994%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo (English)

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27 December 2019

1 reference

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2

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27 December 2019

Michael G Schlossmacher

4

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27 December 2019

author name string

Magali Periquet

1

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27 December 2019

Liisa Myllykangas

3

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27 December 2019

Mel B Feany

5

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27 December 2019

language of work or name

English

0 references

publication date

1 March 2007

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27 December 2019

published in

Journal of Neuroscience

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27 December 2019

volume

27

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27 December 2019

page(s)

3338-3346

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27 December 2019

issue

12

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Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

27 December 2019

cites work

1 reference

12 December 2020

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

12 December 2020

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

1 reference

12 December 2020

A Drosophila model of Parkinson's disease

1 reference

12 December 2020

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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12 December 2020

alpha-Synuclein membrane interactions and lipid specificity

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12 December 2020

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

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12 December 2020

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

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12 December 2020

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12 December 2020

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

1 reference

12 December 2020

"Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders.

1 reference

12 December 2020

Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity

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12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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12 December 2020

A role for alpha-synuclein in the regulation of dopamine biosynthesis

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12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

12 December 2020

Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation

1 reference

12 December 2020

Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.

1 reference

12 December 2020

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

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12 December 2020

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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12 December 2020

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

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12 December 2020

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

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12 December 2020

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.

1 reference

12 December 2020

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

12 December 2020

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

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12 December 2020

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

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12 December 2020

Methionine oxidation, alpha-synuclein and Parkinson's disease

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12 December 2020

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

12 December 2020

Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila

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12 December 2020

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

12 December 2020

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

1 reference

12 December 2020

The biochemistry of Parkinson's disease

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12 December 2020

Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.

1 reference

12 December 2020

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

1 reference

12 December 2020

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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12 December 2020

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.

1 reference

12 December 2020

Prevention of apoptosis by a baculovirus gene during infection of insect cells

1 reference

12 December 2020

Prevalence of movement disorders in elderly community residents

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12 December 2020

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

12 December 2020

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

12 December 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

12 December 2020

10.1523/JNEUROSCI.0285-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17376994%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17376994%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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