(Q45041133)

English

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

scientific article published in September 2004

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

phosphorylation

1 reference

based on heuristic

inferred from title

1

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Europe PubMed Central

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1 January 2020

5

object named as

Mark P Mattson

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Charles DeCarli

3

object named as

Charles DeCarli

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Nicholas J Anders

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Sic L Chan

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Jeffrey A Johnson

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

language of work or name

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publication date

1 September 2004

1 reference

Europe PubMed Central

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1 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

24

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

35

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

7707-7717

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau is essential to beta -amyloid-induced neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent changes in ARE-driven gene expression by use of a noise-filtering process for microarray data

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum insulin-like growth factor I regulates brain amyloid-beta levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The evolution of transthyretin synthesis in the choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin Val122Ile, accumulated Abeta, and inclusion-body myositis aspects in cultured muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces paired helical filament-like tau filaments in tissue culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic programming by the proteolytic fragments of the amyloid precursor protein: somewhere between confusion and clarity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbiased stereological estimation of the number of neurons in the human hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of synaptic development in hippocampal organotypic cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin gene in Alzheimer's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo time course for elimination of adrenalectomy-induced apoptotic profiles from the granule cell layer of the rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15342738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2211-04.2004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15342738%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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