(Q30821694)

19 August 2017

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome (English)

1 reference

19 August 2017

1 reference

1 reference

phenotypic plasticity

1 reference

12

Craig W Lindsley

1 reference

19 August 2017

14

Colleen M Niswender

1 reference

19 August 2017

13

P Jeffrey Conn

1 reference

19 August 2017

5

Rocio Zamorano

1 reference

19 August 2017

7

Shaun R Stauffer

1 reference

19 August 2017

1

Rocco G Gogliotti

1 reference

19 August 2017

2

Rebecca K Senter

1 reference

19 August 2017

6

Chrysa Malosh

1 reference

19 August 2017

11

Carrie K Jones

1 reference

19 August 2017

Jerri M Rook

3

1 reference

19 August 2017

Ayan Ghoshal

4

1 reference

19 August 2017

Thomas M Bridges

8

1 reference

19 August 2017

Jose M Bartolome

9

1 reference

19 August 2017

J Scott Daniels

10

1 reference

19 August 2017

2 March 2016

1 reference

19 August 2017

Human Molecular Genetics

1 reference

19 August 2017

25

1 reference

19 August 2017

10

1 reference

19 August 2017

1990-2004

1 reference

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Gait initiation in children with Rett syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Epilepsy in Rett syndrome, and CDKL5- and FOXG1-gene-related encephalopathies.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

MeCP2 phosphorylation is required for modulating synaptic scaling through mGluR5.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

The pathophysiology of fragile X (and what it teaches us about synapses)

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Mutations causing syndromic autism define an axis of synaptic pathophysiology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Correction of respiratory disorders in a mouse model of Rett syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Metabotropic glutamate receptors: physiology, pharmacology, and disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Fragile X: translation in action

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Tuberous sclerosis complex and epilepsy: recent developments and future challenges

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Synaptic regulation of translation of dendritic mRNAs.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Natural history of Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Therapeutic implications of the mGluR theory of fragile X mental retardation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

The mGluR theory of fragile X mental retardation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Plasticity and primary motor cortex

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Neuropathologic findings associated with seizures in FVB mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

The Rett syndrome: magnetic resonance imaging and clinical findings in four girls

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Rett syndrome: cerebellar pathology.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Cerebellar and cerebral abnormalities in Rett syndrome: a quantitative MR analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain

14 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Characterizing human ion channels in induced pluripotent stem cell-derived neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Immunochemical localization of the metabotropic glutamate receptors in the rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Strengthening of horizontal cortical connections following skill learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Motor cortex rules for learning and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW074

Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062588

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Learning-induced LTP in neocortex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Clinical symptoms of the Rett syndrome patients with MECP2 gene abnormalities]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDW074

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

26936821

1 reference