(Q30855103)

16 November 2017

4 references

25 April 2019

2 October 2019

20 November 2019

15 December 2019

Selective amyloid-beta lowering agents (English)

1 reference

16 November 2017

4 references

25 April 2019

2 October 2019

20 November 2019

15 December 2019

1 reference

2 October 2019

1 reference

20 November 2019

1 reference

15 December 2019

Michael S Wolfe

1

1 reference

16 November 2017

3 December 2008

5 references

16 November 2017

25 April 2019

2 October 2019

20 November 2019

15 December 2019

5 references

16 November 2017

25 April 2019

2 October 2019

20 November 2019

15 December 2019

9 Suppl 2

1 reference

16 November 2017

S4

1 reference

Creative Commons Attribution 2.0 Generic

16 November 2017

4 references

25 April 2019

2 October 2019

20 November 2019

on focus list of Wikimedia project

15 December 2019

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Substrate-targeting gamma-secretase modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Control of peripheral nerve myelination by the beta-secretase BACE1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

The gamma-secretase complex: membrane-embedded proteolytic ensemble

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Gleevec inhibits β-amyloid production but not Notch cleavage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

Gamma-secretase: proteasome of the membrane?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604888

10.1186/1471-2202-9-S2-S4

25 November 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

16 November 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2202-9-s2-s4

1 reference

16 November 2017

PubMed publication ID

19090992

1 reference