(Q36300032)

13 August 2017

1 reference

title

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease (English)

1 reference

13 August 2017

0 references

Dirk Beher

1

1 reference

PubMed ID

16255678

13 August 2017

Samuel L Graham

series ordinal

2

1 reference

PubMed ID

16255678

13 August 2017

language of work or name

English

0 references

publication date

1 November 2005

1 reference

Expert Opinion on Investigational Drugs

13 August 2017

1 reference

13 August 2017

14

1 reference

13 August 2017

11

1 reference

13 August 2017

1385-1409

1 reference

Prevalence of AD among whites: a summary by levels of severity

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Amyloid, the presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Expression and cellular localization of amyloid beta-protein precursor transcripts in normal human brain and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Junctions between intimately apposed cell membranes in the vertebrate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin-dependent processing and nuclear function of gamma-protocadherins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Aryl sulfones: a new class of gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch signaling in T- and B-cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch regulation of lymphocyte development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Control of endodermal endocrine development by Hes-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Purification and characterization of the human gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Human β-Secretase (BACE) and BACE Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Follow the protons: a low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Apo and inhibitor complex structures of BACE (beta-secretase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Human BACE forms dimers and colocalizes with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

BACE1 and BACE2 in pathologic and normal human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

BACE (beta-secretase) modulates the processing of APLP2 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Structure and mechanism of the pepsin-like family of aspartic peptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

Notch signals control the fate of immature progenitor cells in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1385

10.1517/13543784.14.11.1385

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16255678