(Q40559863)

21 September 2017

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function (English)

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21 September 2017

6

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21 September 2017

Indranil Das

1

1 reference

21 September 2017

Colleen Craig

2

1 reference

21 September 2017

Yasuhiro Funahashi

3

1 reference

21 September 2017

Kwang-Mook Jung

4

1 reference

21 September 2017

Tae-Wan Kim

5

1 reference

21 September 2017

Andrew P Weng

7

1 reference

21 September 2017

Jeffery L Kutok

8

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21 September 2017

Jon C Aster

9

1 reference

21 September 2017

Jan Kitajewski

10

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21 September 2017

language of work or name

English

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publication date

3 May 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

29

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21 September 2017

30771-30780

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

The presenilins in Alzheimer's disease--proteolysis holds the key.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Identification and characterization of presenilin-independent Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Lack of requirement for presenilin1 in Notch1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Evidence for a physical interaction between presenilin and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309252200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309252200

1 reference

release_fj446ub2rnd2hpwsltjbp7dcue

21 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fj446ub2rnd2hpwsltjbp7dcue

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference