(Q30988835)

28 June 2017

title

Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development (English)

1 reference

28 June 2017

Mary E Spilker

1

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28 June 2017

Pratap Singh

series ordinal

2

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28 June 2017

Paolo Vicini

series ordinal

3

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28 June 2017

publication date

21 August 2015

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Cytometry Part B: Clinical Cytometry

28 June 2017

published in

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28 June 2017

volume

90

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28 June 2017

issue

2

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28 June 2017

page(s)

230-236

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On setting the first dose in man: quantitating biotherapeutic drug-target binding through pharmacokinetic and pharmacodynamic models.

28 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.B.21318

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21 January 2018

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21 January 2018

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General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

21 January 2018

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Modeling, simulation, and translation framework for the preclinical development of monoclonal antibodies

21 January 2018

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A model-based approach to predicting the human pharmacokinetics of a monoclonal antibody exhibiting target-mediated drug disposition

21 January 2018

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Quantitative prediction of human pharmacokinetics for mAbs exhibiting target-mediated disposition

21 January 2018

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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

21 January 2018

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Target-mediated drug disposition and dynamics

21 January 2018

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A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design

21 January 2018

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21 January 2018

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Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human

21 January 2018

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Development of a PBPK model for monoclonal antibodies and simulation of human and mice PBPK of a radiolabelled monoclonal antibody

21 January 2018

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

21 January 2018

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Measuring drug-related receptor occupancy with positron emission tomography

21 January 2018

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Target site occupancy: emerging generalizations from clinical and preclinical studies

21 January 2018

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In vitro and clinical investigation of the relationship between CCR5 receptor occupancy and anti-HIV activity of Aplaviroc

21 January 2018

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pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

21 January 2018

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Population pharmacokinetic/pharmacodynamic analysis of CCR5 receptor occupancy by maraviroc in healthy subjects and HIV-positive patients.

21 January 2018

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Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

21 January 2018

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7 January 2021

Ligand/receptor internalization: a kinetic, flow cytometric analysis of the internalization of N-formyl peptides by human neutrophils

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.B.21318

7 January 2021

Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies

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https://api.crossref.org/works/10.1002%2FCYTO.B.21318

7 January 2021

Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.B.21318

7 January 2021

Identifiers

DOI

10.1002/CYTO.B.21318

1 reference

release_onvz4al5gzbn7ogahjivdo3che

28 June 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/onvz4al5gzbn7ogahjivdo3che

24 November 2022

mapped directly with Wikidata item

1 reference