(Q30993837)

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(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus (English)

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

status epilepticus

1 reference

based on heuristic

inferred from title

blood–brain barrier

1 reference

based on heuristic

inferred from title

exposure assessment

1 reference

based on heuristic

inferred from title

Albert D. Windhorst

4

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

object named as

Stina Syvänen

1

0 references

Adriaan A Lammertsma

object named as

Adriaan A Lammertsma

6

0 references

Elizabeth C de Lange

object named as

Elizabeth C de Lange

8

0 references

2

object named as

Gert Luurtsema

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Carla F M Molthoff

3

object named as

Carla F M Molthoff

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

7

object named as

Rob A Voskuyl

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

author name string

Marc C Huisman

5

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

publication date

3 January 2011

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

BMC Medical Imaging

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

11

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

copyright license

Creative Commons Attribution 2.0 Generic

3 January 2011

1 reference

April 2022 Public Data File from Crossref

Creative Commons Attribution 2.0 Generic

0 references

copyright status

1 reference

April 2022 Public Data File from Crossref

Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach.

1 reference

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The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins

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Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

1 reference

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Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection

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Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

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P-glycoprotein--a clinical target in drug-refractory epilepsy?

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms

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Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats

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14 July 2018

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

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14 July 2018

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

1 reference

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14 July 2018

Positron emission tomography compartmental models

1 reference

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14 July 2018

A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier

1 reference

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14 July 2018

Clinical aspects and biological bases of drug-resistant epilepsies

1 reference

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14 July 2018

MDR1 gene expression in brain of patients with medically intractable epilepsy

1 reference

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14 July 2018

Modification of seizure activity by electrical stimulation. 3. Mechanisms

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14 July 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

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14 July 2018

Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

1 reference

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Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats

1 reference

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14 July 2018

The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy

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https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.

1 reference

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Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

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21 January 2018

Over-expression of P-glycoprotein in malformations of cortical development.

1 reference

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21 January 2018

Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

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How to explain multidrug resistance in epilepsy?

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

1 reference

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21 January 2018

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

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In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

1 reference

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21 January 2018

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

1 reference

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21 January 2018

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

1 reference

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Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2342-11-1

21 January 2018

Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function.

1 reference

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25 November 2018

Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

1 reference

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Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

1 reference

https://pubmed.ncbi.nlm.nih.gov/21199574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21199574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2342-11-1

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

DBLP publication ID

journals/bmcmi/SyvanenLMWHLVL11

1 reference

DBLP Dataset 2021-01-02

28 January 2021

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2342-11-1

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

ResearchGate publication ID

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