(Q30994890)

English

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

3

object named as

Xiuqing Huang

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

author name string

Huiping Yuan

1

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Xiaoyong Zhang

2

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Yonggang Lu

4

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Weiqing Tang

5

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Yong Man

6

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Shu Wang

7

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Jianzhong Xi

8

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Jian Li

9

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

language of work or name

0 references

publication date

29 December 2010

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

5

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

12

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

e15726

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

copyright license

Creative Commons Attribution 4.0 International

29 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.

1 reference

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21 June 2018

Oxidative stress and oxidative damage in carcinogenesis

1 reference

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21 June 2018

Abnormalities in insulin secretion in type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

New insights into fatty acid modulation of pancreatic beta-cell function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The pathobiology of diabetic complications: a unifying mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Role of oxidative stress in pancreatic beta-cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

25 November 2018

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

A central role for JNK in obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0015726

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

2010PLoSO...515726Y

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

ResearchGate publication ID

0 references

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