(Q31023819)

English

The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

scientific article published on December 1, 2003

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scholarly article

1 reference

Europe PubMed Central

18 September 2017

The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53 (English)

1 reference

10.1128/MCB.23.23.8846-8861.2003

https://api.crossref.org/works/10.1128/MCB.23.23.8846-8861.2003

31 March 2024

1 reference

10.1128/MCB.23.23.8846-8861.2003

https://api.crossref.org/works/10.1128/MCB.23.23.8846-8861.2003

31 March 2024

author name string

David Dornan

1

1 reference

Europe PubMed Central

18 September 2017

Harumi Shimizu

2

1 reference

Europe PubMed Central

18 September 2017

Lindsay Burch

3

1 reference

Europe PubMed Central

18 September 2017

Amanda J. Smith

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

Ted R. Hupp

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

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publication date

1 December 2003

1 reference

Europe PubMed Central

18 September 2017

full work available at URL

https://europepmc.org/articles/pmc262654?pdf=render

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online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

https://europepmc.org/articles/PMC262654

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

https://europepmc.org/articles/PMC262654?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

https://doi.org/10.1128/mcb.23.23.8846-8861.2003

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612423

31 March 2024

https://journals.asm.org/doi/pdf/10.1128/MCB.23.23.8846-8861.2003

1 reference

10.1128/MCB.23.23.8846-8861.2003

https://api.crossref.org/works/10.1128/MCB.23.23.8846-8861.2003

31 March 2024

https://www.tandfonline.com/doi/pdf/10.1128/MCB.23.23.8846-8861.2003

1 reference

10.1128/MCB.23.23.8846-8861.2003

https://api.crossref.org/works/10.1128/MCB.23.23.8846-8861.2003

31 March 2024

Molecular and Cellular Biology

1 reference

Europe PubMed Central

18 September 2017

23

1 reference

Europe PubMed Central

18 September 2017

8846-8861

1 reference

Europe PubMed Central

18 September 2017

23

1 reference

Europe PubMed Central

18 September 2017

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Identification and characterization of peptide probes directed against PKCalpha conformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

DNA-dependent acetylation of p53 by the transcription coactivator p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

p53 contains large unstructured regions in its native state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Why is p53 acetylated?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Interaction between acetylated MyoD and the bromodomain of CBP and/or p300

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

p300 forms a stable, template-committed complex with chromatin: role for the bromodomain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

p300/CBP/p53 interaction and regulation of the p53 response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

CBP/p300 in cell growth, transformation, and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Acetylation: a regulatory modification to rival phosphorylation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Regulation of E2F1 activity by acetylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

Allosteric activation of latent p53 tetramers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

21 June 2018

The IARC TP53 database: new online mutation analysis and recommendations to users

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

Allosteric effects of DNA on transcriptional regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262654

25 November 2018

Function for p300 and not CBP in the apoptotic response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/14612423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/14612423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/14612423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.23.23.8846-8861.2003

1 reference

Europe PubMed Central

18 September 2017

1 reference

Europe PubMed Central

18 September 2017

1 reference

Europe PubMed Central

18 September 2017

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