(Q31110554)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

review article

1 reference

title

Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

4

Paul Boon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

3

Kristl Vonck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

2

Robrecht Raedt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1

Tim De Smedt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

CNS Neuroscience & Therapeutics

29 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

page(s)

43-56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons

29 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Antiepileptic drugs and apoptotic neurodegeneration in the developing brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Effects of levetiracetam on spike and wave discharges in WAG/Rij rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The antiepileptic drug levetiracetam decreases the inositol 1,4,5-trisphosphate-dependent [Ca2+]I increase induced by ATP and bradykinin in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Prevention of epileptic seizures by taurine.

21 January 2018

2 references

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

21 January 2018

12 December 2020

Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The synaptic vesicle protein SV2 is a novel type of transmembrane transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam: antiepileptic properties and protective effects on mitochondrial dysfunction in experimental status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Effect of levetiracetam on epileptiform discharges in human neocortical slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

ucb L059, a novel anti-convulsant drug: pharmacological profile in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing p

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Developmental Outcome of Levetiracetam, Its Major Metabolite in Humans, 2‐Pyrrolidinone N‐Butyric Acid, and Its Enantiomer (R)‐α‐ethyl‐oxo‐pyrrolidine Acetamide in a Mouse Model of Teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Absence of negative impact of levetiracetam on cognitive function and memory in normal and amygdala-kindled rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Selective blockade of N-type calcium channels by levetiracetam

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam protects against kainic acid-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Cellular and field potential properties of epileptogenic hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Mechanisms of antiepileptic drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Pharmacological Prophylaxis in the Kindling Model of Epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

SV2 modulates the size of the readily releasable pool of secretory vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00004.X

Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats

21 January 2018

1 reference

12 December 2020

Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats

1 reference

12 December 2020

Piracetam and levetiracetam: close structural similarities but different pharmacological and clinical profiles

1 reference

12 December 2020

Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam.

1 reference

12 December 2020

Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?

1 reference

12 December 2020

Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices

1 reference

12 December 2020

Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice

1 reference

12 December 2020

Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement

1 reference

12 December 2020

Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER).

1 reference

12 December 2020

SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment

1 reference

12 December 2020

Synaptic vesicle protein 2 enhances release probability at quiescent synapses

1 reference

12 December 2020

Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.

1 reference

12 December 2020

Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia.

1 reference

12 December 2020

Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.

1 reference

12 December 2020

Administration of levetiracetam after prolonged status epilepticus does not protect from mitochondrial dysfunction in a rodent model

1 reference

12 December 2020

Ontogeny of absence-like and tonic seizures in the spontaneously epileptic rat

1 reference

12 December 2020

Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy

1 reference

12 December 2020

ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo

1 reference

12 December 2020

The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata.

1 reference

12 December 2020

Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy

1 reference

12 December 2020

Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus

1 reference

12 December 2020

Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission

1 reference

12 December 2020

Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy

1 reference

12 December 2020

10.1111/J.1527-3458.2007.00004.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17461889%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

17461889

1 reference