(Q31814838)

4 July 2017

title

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes (English)

1 reference

4 July 2017

0 references

BLM RecQ like helicase

1 reference

regulation of DNA-dependent DNA replication

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jan Steyaert

9

1 reference

4 July 2017

2

Pavel Savitsky

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Anna H Bizard

object named as

Anna H Bizard

4

0 references

Joseph A Newman

object named as

Joseph A Newman

1

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Opher Gileadi

object named as

Opher Gileadi

11

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author name string

Pavel Savitsky

2

1 reference

4 July 2017

Charles K Allerston

3

1 reference

4 July 2017

Özgün Özer

5

1 reference

4 July 2017

Kata Sarlós

6

1 reference

4 July 2017

Ying Liu

7

1 reference

4 July 2017

Els Pardon

8

1 reference

4 July 2017

Ian D Hickson

10

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4 July 2017

language of work or name

English

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publication date

21 April 2015

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4 July 2017

published in

Nucleic Acids Research

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4 July 2017

volume

43

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4 July 2017

issue

10

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4 July 2017

page(s)

5221-5235

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Creative Commons Attribution 4.0 International

4 July 2017

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

21 June 2018

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The dissolution of double Holliday junctions

21 June 2018

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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

21 June 2018

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A general protocol for the generation of Nanobodies for structural biology

21 June 2018

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Structure of the RecQ C-terminal domain of human Bloom syndrome protein

21 June 2018

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Comprehensive macromolecular conformations mapped by quantitative SAXS analyses

21 June 2018

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Accurate assessment of mass, models and resolution by small-angle scattering

21 June 2018

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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

21 June 2018

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Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

21 June 2018

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Towards automated crystallographic structure refinement with phenix.refine

21 June 2018

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Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.

21 June 2018

1 reference

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Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

21 June 2018

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Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

21 June 2018

1 reference

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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

21 June 2018

1 reference

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Critical interaction domains between bloom syndrome protein and RAD51

21 June 2018

1 reference

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A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Solution structure of the HRDC domain of human Bloom syndrome protein BLM

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structure and function of the regulatory HRDC domain from human Bloom syndrome protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

High-throughput production of human proteins for crystallization: the SGC experience.

21 June 2018

1 reference

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Probing the structural basis of RecQ helicase function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Features and development of Coot

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Dissolution of double Holliday junctions by the concerted action of BLM and topoisomerase IIIalpha

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

RecQ helicases: multifunctional genome caretakers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Phasercrystallographic software

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structural basis for DNA duplex separation by a superfamily-2 helicase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Coupling DNA-binding and ATP hydrolysis in Escherichia coli RecQ: role of a highly conserved aromatic-rich sequence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The HRDC domain of BLM is required for the dissolution of double Holliday junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Global rigid body modeling of macromolecular complexes against small-angle scattering data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

High-resolution structure of the E.coli RecQ helicase catalytic core

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Structural and functional homology between the RNAP(I) subunits A14/A43 and the archaeal RNAP subunits E/F.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Helicase motif Ia is involved in single-strand DNA-binding and helicase activities of the herpes simplex virus type 1 origin-binding protein, UL9.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's syndrome gene product promotes branch migration of holliday junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's syndrome gene product interacts with topoisomerase III

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

The Bloom's syndrome gene product is a 3'-5' DNA helicase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446433

A rapid method for determining dynamic binding capacity of resins for the purification of proteins.

21 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKV373

CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKV373

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKV373

Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKV373

CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN

21 January 2018

1 reference

12 December 2020

Importance of F1-ATPase residue alpha-Arg-376 for catalytic transition state stabilization

1 reference

12 December 2020

Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes

1 reference

12 December 2020

Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKV373

1 reference

4 July 2017

1 reference

4 July 2017

1 reference