(Q32022023)

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A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Alzheimer's disease

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endoplasmic reticulum

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phosphorylation

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author name string

T Kawamata

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

T Taniguchi

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

H Mukai

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

M Kitagawa

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

T Hashimoto

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

K Maeda

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Y Ono

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

C Tanaka

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

language of work or name

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publication date

1 September 1998

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

18

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

18

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

7402-7410

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Purification and characterization of a fatty acid-activated protein kinase (PKN) from rat testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune system response in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 and its role in brain tissue.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the interaction between RhoA and the amino-terminal region of PKN

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein function in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase C family for neuronal signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure, expression, and properties of additional members of the protein kinase C family

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential phosphorylation of tau by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II: metabolic and functional consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A neuronal antigen in the brains of Alzheimer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of nuclear tau isoforms in human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKN associates and phosphorylates the head-rod domain of neurofilament protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of PKN with alpha-actinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation of PKN from the cytosol to the nucleus induced by stresses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9736660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.18-18-07402.1998

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736660%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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