(Q3271142)

English

cytochrome P450 family 2 subfamily D member 6

mammalian protein found in Homo sapiens

xenobiotic monooxygenase
CYP2D6
cytochrome P450 2D6
nonfunctional cytochrome P450 2D6
cytochrome P450-DB1
cytochrome P450, family 2, subfamily D, polypeptide 6
cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2
cholesterol 25-hydroxylase
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
debrisoquine 4-hydroxylase
cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
flavoprotein-linked monooxygenase
microsomal monooxygenase
CYPIID6
Cytochrome P-450 CYP2D6

In more languages

Statements

1 reference

20 December 2017

UniProt protein ID

cytochrome P450 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10635

cytochrome P450, E-class, group I, CYP2D-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10635

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

20 December 2017

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

molecular function

iron ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

oxidoreductase activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

aromatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

steroid hydroxylase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

monooxygenase activity

determination method

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10635&geneProductId=UniProtKB:P10635

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10635&geneProductId=UniProtKB:P10635

determination method

10 September 2018

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10635&geneProductId=UniProtKB:P10635

determination method

10 September 2018

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10635&geneProductId=UniProtKB:P10635

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method

3 references

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Crystal structure of human cytochrome P450 2D6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

monooxygenase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

organelle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

intracellular membrane-bounded organelle

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10635&geneProductId=UniProtKB:P10635

determination method

determination method

1 reference

8 April 2019

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

biological process

alkaloid metabolic process

determination method

1 reference

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

coumarin metabolic process

determination method

1 reference

8 April 2019

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

isoquinoline alkaloid metabolic process

determination method

1 reference

8 April 2019

CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

alkaloid catabolic process

determination method

1 reference

8 April 2019

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

negative regulation of binding

determination method

1 reference

8 April 2019

CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

monoterpenoid metabolic process

determination method

1 reference

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

arachidonic acid metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

negative regulation of cellular organofluorine metabolic process

determination method

1 reference

8 April 2019

CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

long-chain fatty acid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

organic acid metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

xenobiotic metabolic process

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10635

determination method

physically interacts with

liver kidney microsomal type 1 antibody

subject has role

0 references

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Gene Atlas image

PBB GE CYP2D6 207498 s at fs.png
732 × 530; 8 KB

0 references

cytochrome P450, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10635

Identifiers

MeSH descriptor ID

subject named as

Cytochrome P-450 CYP2D6

0 references

D08.244.453.005.600

0 references

D08.244.453.491.372

0 references

D08.811.682.690.708.170.010.600

0 references

D08.811.682.690.708.170.450.368

0 references

D12.776.422.220.453.010.600

0 references

D12.776.422.220.453.491.368

0 references

RefSeq protein ID

1 reference

6 January 2018

1 reference

6 January 2018

UniProt protein ID

0 references

Ensembl protein ID

ENSP00000351927

0 references

ENSP00000353820

0 references

ENSP00000483677

0 references

ENSP00000490398

0 references

ENSP00000483245

0 references

ENSP00000487281

0 references

ENSP00000479867

0 references

ENSP00000374620

0 references

ENSP00000489990

0 references

ENSP00000476021

0 references

ENSP00000486094

0 references

ENSP00000489103

0 references

ENSP00000486619

0 references

ENSP00000490065

0 references

ENSP00000489144

0 references

ENSP00000489231

0 references

ENSP00000487558

0 references

ENSP00000488991

0 references

ENSP00000489906

0 references

ENSP00000353241

0 references

ENSP00000487214

0 references

ENSP00000496150

0 references

ENSP00000494517

0 references

ENSP00000493632

0 references

ENSP00000495894

0 references

ENSP00000493682

0 references

ENSP00000496296

0 references

ENSP00000493553

0 references

ENSP00000493804

0 references

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(17 entries)

arwiki سيتوكروم 2D6
cywiki CYP2D6
dewiki Cytochrom P450 2D6
enwiki CYP2D6
eswiki CYP2D6
etwiki Tsütokroom P450 2D6
fawiki CYP2D6
frwiki Cytochrome CYP2D6
idwiki Sitokrom P450 2D6
itwiki CYP2D6
jawiki CYP2D6
kowiki CYP2D6
lawiki CYP2D6
mkwiki CYP2D6
ptwiki CYP2D6
ukwiki CYP2D6
zhwiki CYP2D6

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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