(Q24298673)

GOA release 2020-03-11

heme binding

1 reference

GOA release 2020-03-11

8

Mike G Tennant

0 references

author name string

Paul Rowland

1

0 references

Frank E Blaney

2

0 references

Martin G Smyth

3

0 references

Jo J Jones

4

0 references

Vaughan R Leydon

5

0 references

Amanda K Oxbrow

6

0 references

Ceri J Lewis

7

0 references

Sandeep Modi

9

0 references

Drake S Eggleston

10

0 references

Richard J Chenery

11

0 references

Angela M Bridges

Journal of Biological Chemistry

12

0 references

language of work or name

English

0 references

publication date

17 March 2006

0 references

published in

0 references

volume

281

0 references

issue

11

0 references

page(s)

7614-22

0 references

cites work

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Cytochrome p450 in silico: an integrative modeling approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modification of its N-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The CCP4 suite: programs for protein crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Likelihood-enhanced fast rotation functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Use of non-crystallographic symmetry in protein structure refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Detection, delineation, measurement and display of cavities in macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The catalytic pathway of cytochrome p450cam at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Mechanism and structure-reactivity relationships for aromatic hydroxylation by cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Catalytic specificity of CYP2D isoforms in rat and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

Deletion of a conserved tetrapeptide, PPGP, in P450 2C2 results in loss of enzymatic activity without a change in its cellular location

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Cumene hydroperoxide-supported demethylation reactions catalyzed by cytochrome P450 2B4 lacking the NH2-terminal sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511232200

7 January 2021

Identifiers

DOI

10.1074/JBC.M511232200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16352597

1 reference

Consolidated OpenCitations Corpus – April 2017