(Q33196330)

23 July 2017

Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity (English)

1 reference

23 July 2017

1 reference

1 reference

Martin J Richer

1

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23 July 2017

Luiz Juliano

series ordinal

2

1 reference

23 July 2017

Carl Hashimoto

series ordinal

3

1 reference

23 July 2017

François Jean

series ordinal

4

1 reference

23 July 2017

language of work or name

English

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publication date

29 December 2003

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Journal of Biological Chemistry

23 July 2017

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23 July 2017

279

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23 July 2017

10222-10227

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23 July 2017

11

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Hepatitis C therapeutics: current status and emerging strategies

23 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Recent advances in the molecular biology of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Interaction between hepatitis C virus proteins and host cell factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Inhibiting viral proteases: challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

A protein-based therapeutic for human cytomegalovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

A novel Drosophila serpin that inhibits serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Expression of highly active recombinant NS3 protease domain of hepatitis C virus in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Virus-encoded proteinases of the Flaviviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Conformational changes in human hepatitis C virus NS3 protease upon binding of product-based inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

Active-site titration of peptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313852200

21 January 2018

Identifiers

DOI

10.1074/JBC.M313852200

1 reference

23 July 2017

1 reference