(Q33309679)

25 July 2017

title

Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives (English)

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25 July 2017

main subject

Plasmodium falciparum

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David Hecht

4

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author name string

Gary B Fogel

series ordinal

1

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25 July 2017

Mars Cheung

series ordinal

2

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25 July 2017

Eric Pittman

series ordinal

3

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25 July 2017

language of work or name

1 reference

11 December 2007

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Journal of Computer - Aided Molecular Design

25 July 2017

published in

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25 July 2017

volume

22

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25 July 2017

issue

1

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25 July 2017

page(s)

29-38

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Identification of the optimal third generation antifolate against P. falciparum and P. vivax

25 July 2017

cites work

1 reference

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Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.

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Development of neural network QSPR models for Hansch substituent constants. 2. Applications in QSAR studies of HIV-1 reverse transcriptase and dihydrofolate reductase inhibitors

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The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

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A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

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LigScore: a novel scoring function for predicting binding affinities

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Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance

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Protein flexibility in ligand docking and virtual screening to protein kinases.

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12 December 2020

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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12 December 2020

Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

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12 December 2020

10.1007/S10822-007-9152-9

Identifiers

DOI

1 reference

journals/jcamd/FogelCPH08

25 July 2017

DBLP publication ID

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DBLP Dataset 2021-01-02

28 January 2021

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