(Q33332189)

25 July 2017

title

Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas (English)

1 reference

25 July 2017

1 reference

George Horng

7

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Sylvie Giuriato

object named as

Sylvie Giuriato

9

0 references

Phuoc T. Tran

object named as

Phuoc T Tran

1

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author name string

Alice C Fan

2

1 reference

25 July 2017

Pavan K Bendapudi

3

1 reference

25 July 2017

Shan Koh

4

1 reference

25 July 2017

Kim Komatsubara

5

1 reference

25 July 2017

Joy Chen

6

1 reference

25 July 2017

David I Bellovin

8

1 reference

25 July 2017

Craig S Wang

10

1 reference

25 July 2017

Jeffrey A Whitsett

11

1 reference

25 July 2017

Dean W Felsher

12

1 reference

25 July 2017

language of work or name

English

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publication date

7 May 2008

1 reference

25 July 2017

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25 July 2017

volume

3

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25 July 2017

issue

5

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25 July 2017

page(s)

e2125

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Creative Commons Attribution 4.0 International

25 July 2017

copyright license

start time

7 May 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

21 June 2018

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Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

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21 June 2018

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Conditional transgenic models define how MYC initiates and maintains tumorigenesis

21 June 2018

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Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis

21 June 2018

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

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"Oncogenic shock": explaining oncogene addiction through differential signal attenuation

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21 June 2018

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

21 June 2018

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21 June 2018

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21 June 2018

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Somatic mutations of the protein kinase gene family in human lung cancer

21 June 2018

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The concept of synthetic lethality in the context of anticancer therapy

21 June 2018

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ERBB2 kinase domain mutation in the lung squamous cell carcinoma

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Getting at MYC through RAS.

21 June 2018

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21 June 2018

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21 June 2018

Targeted cancer therapy

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Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

21 June 2018

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

21 June 2018

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

21 June 2018

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

21 June 2018

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21 June 2018

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

21 June 2018

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The STATs of cancer--new molecular targets come of age

21 June 2018

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Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Distinct requirements for Ras oncogenesis in human versus mouse cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 June 2018

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Modelling the molecular circuitry of cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Reversible tumorigenesis by MYC in hematopoietic lineages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Essential role for oncogenic Ras in tumour maintenance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Differentiation-linked leukemogenesis in lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 June 2018

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21 January 2018

Molecular on/off switch.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002125

Conditional gene expression in the respiratory epithelium of the mouse.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002125

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002125

Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer

21 January 2018

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EGFR and erbB2 mutation status in Japanese lung cancer patients

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002125

Uncommon V599E BRAF mutations in Japanese patients with lung cancer

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002125

Missense mutations of the BRAF gene in human lung adenocarcinoma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365560

HER3 and mutant EGFR meet MET

31 October 2018

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12 December 2020

Sustained loss of a neoplastic phenotype by brief inactivation of MYC

1 reference

12 December 2020

BRAF and RAS mutations in human lung cancer and melanoma

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12 December 2020

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

1 reference

12 December 2020

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

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12 December 2020

Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models

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12 December 2020

10.1371/JOURNAL.PONE.0002125

Identifiers

DOI

1 reference

25 July 2017

0 references

1 reference

25 July 2017

1 reference