(Q33391858)

26 July 2017

title

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II. (English)

1 reference

26 July 2017

7

Daniel D Billadeau

1 reference

26 July 2017

Lisa M Oppegard

1

1 reference

26 July 2017

Andrei V Ougolkov

2

1 reference

26 July 2017

Doris N Luchini

3

1 reference

26 July 2017

Renee A Schoon

4

1 reference

26 July 2017

John R Goodell

5

1 reference

26 July 2017

Harneet Kaur

6

1 reference

26 July 2017

David M Ferguson

8

1 reference

26 July 2017

Hiroshi Hiasa

9

1 reference

26 July 2017

language of work or name

English

0 references

publication date

3 December 2008

1 reference

European Journal of Pharmacology

26 July 2017

published in

1 reference

26 July 2017

volume

602

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26 July 2017

issue

2-3

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26 July 2017

page(s)

223-229

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Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

26 July 2017

cites work

1 reference

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A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads

21 June 2018

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Interaction of strong DNA-intercalating bioreductive compounds with topoisomerases I and II.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome

21 June 2018

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21 June 2018

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Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin

21 June 2018

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Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

21 June 2018

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Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

21 June 2018

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21 June 2018

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Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

21 June 2018

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Catalytic topoisomerase II inhibitors in cancer therapy.

21 June 2018

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21 June 2018

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Fluoroquinolones: action and resistance

21 June 2018

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21 June 2018

Focus on pancreas cancer

1 reference

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DNA topoisomerase II as a target for cancer chemotherapy.

21 June 2018

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Potent inhibition of DNA unwinding and ATPase activities of pea DNA helicase 45 by DNA-binding agents

21 June 2018

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Cellular roles of dna topoisomerases: a molecular perspective

21 June 2018

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Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

21 June 2018

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DNA topoisomerases: structure, function, and mechanism

21 June 2018

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Tumor cell death induced by topoisomerase-targeting drugs.

21 June 2018

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Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

21 June 2018

1 reference

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DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition.

21 June 2018

1 reference

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DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities.

21 June 2018

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Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique

21 June 2018

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

21 June 2018

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The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues

21 June 2018

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Myeloid leukemia after hematotoxins

21 June 2018

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Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development

21 June 2018

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

21 June 2018

1 reference

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Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain

21 June 2018

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

21 June 2018

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DNA gyrase: structure and function.

21 June 2018

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Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers.

21 June 2018

1 reference

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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637346

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637346

Antitumor activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerases I and II.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637346

Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637346

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

31 October 2018

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12 December 2020

Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180)

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12 December 2020

Secondary leukemias induced by topoisomerase-targeted drugs

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12 December 2020

Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways

1 reference

12 December 2020

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

1 reference

12 December 2020

10.1016/J.EJPHAR.2008.11.044

Identifiers

DOI

1 reference

26 July 2017

1 reference

26 July 2017

1 reference