(Q33396938)

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Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions (English)

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Europe PubMed Central

PubMed publication ID

26 July 2017

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Peter Vogel

1

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author name string

Michael S Donoviel

2

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Europe PubMed Central

PubMed publication ID

26 July 2017

Robert Read

3

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Europe PubMed Central

PubMed publication ID

26 July 2017

Gwenn M Hansen

4

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Europe PubMed Central

PubMed publication ID

26 July 2017

Jill Hazlewood

5

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Europe PubMed Central

PubMed publication ID

26 July 2017

Stephen J Anderson

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Weimei Sun

7

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Europe PubMed Central

PubMed publication ID

26 July 2017

Jonathan Swaffield

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Tamas Oravecz

9

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Europe PubMed Central

PubMed publication ID

26 July 2017

language of work or name

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publication date

1 January 2009

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Europe PubMed Central

PubMed publication ID

26 July 2017

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Europe PubMed Central

PubMed publication ID

26 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

e4112

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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Creative Commons Attribution 4.0 International

1 January 2009

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April 2022 Public Data File from Crossref

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New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

1 reference

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14 July 2018

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

1 reference

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14 July 2018

Finding a way out: lymphocyte egress from lymphoid organs

1 reference

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14 July 2018

FTY720: a most promising immunosuppressant modulating immune cell functions

1 reference

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14 July 2018

PDGF signaling specificity is mediated through multiple immediate early genes

1 reference

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14 July 2018

Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling

1 reference

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14 July 2018

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.

1 reference

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14 July 2018

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Journey through the thymus: stromal guides for T-cell development and selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Emerging medicinal roles for lysophospholipid signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingolipids in inflammation: roles and implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Point-counterpoint of sphingosine 1-phosphate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Storage diseases: new insights into sphingolipid functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Construction of gene targeting vectors from lambda KOS genomic libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

1 reference

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14 July 2018

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Sphingosine-phosphate lyase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

14 July 2018

Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606024

31 October 2018

Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressant FTY720 inhibits thymocyte emigration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulmonary alveolar proteinosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent thymic emigrants are distinct from most medullary thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that FTY720 induces rat thymocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased lung surfactant phosphatidylcholine in patients affected by lysosomal storage diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19119317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0004112

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2009PLoSO...4.4112V

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

0 references

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