(Q33412371)

English

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease

scientific article

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

13

object named as

M Flint Beal

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Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Wencheng Liu

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Cristofol Vives-Bauza

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Rebeca Acín-Peréz-

3

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Ai Yamamoto

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Yingcai Tan

5

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Yanping Li

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Jordi Magrané

7

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Mihaela A Stavarache

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Sebastian Shaffer

9

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Simon Chang

10

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Michael G Kaplitt

11

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Xin-Yun Huang

12

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Giovanni Manfredi

14

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Europe PubMed Central

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26 July 2017

Chenjian Li

15

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Europe PubMed Central

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26 July 2017

language of work or name

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publication date

26 February 2009

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Europe PubMed Central

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26 July 2017

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Europe PubMed Central

PubMed publication ID

26 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

e4597

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

copyright license

Creative Commons Attribution 4.0 International

26 February 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

The PINK1/Parkin pathway regulates mitochondrial morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

The role of mitochondria in inherited neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial modulation: reversible phosphorylation takes center stage?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Modeling mitochondrial function in aging neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Novel PINK1 mutations in early-onset parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

PINK1 mutations are associated with sporadic early-onset parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Protein degradation and protection against misfolded or damaged proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Parkinson's disease: mechanisms and models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Evidence of undiscovered cell regulatory mechanisms: phosphoproteins and protein kinases in mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Quantifying adenoviral titers by spectrophotometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Dehydrogenase activation by Ca2+ in cells and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

21 June 2018

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Measurements of ATP in mammalian cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Proteasome dysfunction in aged human alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004597

21 January 2018

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644779

31 October 2018

Degradation of alpha-synuclein by proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19242547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19242547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial oxidative phosphorylation defects in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19242547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of proteins phosphorylated by the cAMP-dependent protein kinase of bovine heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19242547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0004597

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2009PLoSO...4.4597L

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

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