(Q33419789)

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MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies (English)

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Europe PubMed Central

PubMed publication ID

26 July 2017

Gaurav Choudhary

1

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Alexandru Almasan

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

S Al-Harbi

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

S Mazumder

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

B T Hill

4

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

J Bodo

6

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

E D Hsi

7

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31 May 2020

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15 January 2015

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26 July 2017

Cell Death and Disease

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

6

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

e1593

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31 May 2020

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Creative Commons Attribution 4.0 International

1 January 2015

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4669737/fullTextXML

based on heuristic

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Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.

1 reference

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21 June 2018

Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.

1 reference

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1 reference

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21 June 2018

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

1 reference

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21 June 2018

Richter syndrome

1 reference

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21 June 2018

BH3 mimetics: status of the field and new developments

1 reference

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Evading apoptosis in cancer

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The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways.

1 reference

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21 June 2018

The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma

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21 June 2018

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

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21 June 2018

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21 June 2018

BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.

1 reference

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21 June 2018

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1 reference

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21 June 2018

ABT-199: taking dead aim at BCL-2

1 reference

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21 June 2018

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

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21 June 2018

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

1 reference

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21 June 2018

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

1 reference

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Concurrent inhibition of PI3-kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.

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Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells

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PI3Kδ inhibition hits a sensitive spot in B cell malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25590803

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDDIS.2014.525

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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Europe PubMed Central

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31 May 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590803%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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