(Q35880102)

English

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

scientific article published on 6 February 2012

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation (English)

1 reference

Europe PubMed Central

10 August 2017

(-)-marinopyrrole A

1 reference

ChEBI release 2020-05-28

object named as

Hong-Gang Wang

18

0 references

author name string

Kenichiro Doi

1

1 reference

Europe PubMed Central

10 August 2017

Rongshi Li

2

1 reference

Europe PubMed Central

10 August 2017

Shen-Shu Sung

3

1 reference

Europe PubMed Central

10 August 2017

Hongwei Wu

4

1 reference

Europe PubMed Central

10 August 2017

Yan Liu

5

1 reference

Europe PubMed Central

10 August 2017

Wanda Manieri

6

1 reference

Europe PubMed Central

10 August 2017

Gowdahalli Krishnegowda

7

1 reference

Europe PubMed Central

10 August 2017

Andy Awwad

8

1 reference

Europe PubMed Central

10 August 2017

Alden Dewey

9

1 reference

Europe PubMed Central

10 August 2017

Xin Liu

10

1 reference

Europe PubMed Central

10 August 2017

Shantu Amin

11

1 reference

Europe PubMed Central

10 August 2017

Chunwei Cheng

12

1 reference

Europe PubMed Central

10 August 2017

Yong Qin

13

1 reference

Europe PubMed Central

10 August 2017

Ernst Schonbrunn

14

1 reference

Europe PubMed Central

10 August 2017

Gary Daughdrill

15

1 reference

Europe PubMed Central

10 August 2017

Thomas P Loughran

16

1 reference

Europe PubMed Central

10 August 2017

Said Sebti

17

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

6 February 2012

1 reference

Europe PubMed Central

10 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

10 August 2017

287

1 reference

Europe PubMed Central

10 August 2017

10224-10235

1 reference

Europe PubMed Central

10 August 2017

13

1 reference

Europe PubMed Central

10 August 2017

Targeting Mcl-1 for the therapy of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

1 reference

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11 July 2018

Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus

1 reference

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11 July 2018

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

ARC synergizes with ABT-737 to induce apoptosis in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

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The landscape of somatic copy-number alteration across human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Marinopyrrole A target elucidation by acyl dye transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Simultaneous targeting of MCL1 and ABCB1 as a novel strategy to overcome drug resistance in human leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Bcl-2 family proteins and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Reciprocal protection of Mcl-1 and Bim from ubiquitin-proteasome degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Structural insights into the degradation of Mcl-1 induced by BH3 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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11 July 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

1 reference

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11 July 2018

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

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11 July 2018

A role for mitochondrial Bak in apoptotic response to anticancer drugs

1 reference

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11 July 2018

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

1 reference

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11 July 2018

Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer

1 reference

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11 July 2018

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

1 reference

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11 July 2018

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323047

11 July 2018

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1 reference

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Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes

1 reference

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11 July 2018

Molecular dynamics study of small molecule inhibitors of the Bcl-2 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/22311987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22311987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.334532

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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