(Q38115674)

29 August 2017

Decoding and unlocking the BCL-2 dependency of cancer cells (English)

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29 August 2017

Philippe Juin

1

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29 August 2017

Olivier Geneste

2

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29 August 2017

Fabien Gautier

3

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29 August 2017

Stéphane Depil

4

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29 August 2017

Mario Campone

5

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29 August 2017

language of work or name

English

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publication date

20 June 2013

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29 August 2017

Nature Reviews Cancer

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29 August 2017

13

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29 August 2017

455-465

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29 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrc3538

29 August 2017

0 references

1 reference

Molecular biology of Bax and Bak activation and action

31 March 2020

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Prostaglandins antagonistically control Bax activation during apoptosis

31 March 2020

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Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis

31 March 2020

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

31 March 2020

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

31 March 2020

1 reference

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

31 March 2020

1 reference

MicroRNA 29b functions in acute myeloid leukemia

31 March 2020

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

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Intrinsic tumour suppression

31 March 2020

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

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Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma.

31 March 2020

1 reference

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

31 March 2020

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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

31 March 2020

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Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice

31 March 2020

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

31 March 2020

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c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

31 March 2020

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The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

31 March 2020

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

31 March 2020

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

31 March 2020

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

31 March 2020

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Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

31 March 2020

1 reference

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

31 March 2020

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

31 March 2020

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Regulation of apoptosis: uncovering the binding determinants

31 March 2020

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Structural biology of the Bcl-2 family of proteins

31 March 2020

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Structural plasticity underpins promiscuous binding of the prosurvival protein A1

31 March 2020

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

31 March 2020

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BCL-2 family antagonists for cancer therapy

31 March 2020

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PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

31 March 2020

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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

31 March 2020

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BAX activation is initiated at a novel interaction site

31 March 2020

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BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

31 March 2020

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Direct and selective small-molecule activation of proapoptotic BAX

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

31 March 2020

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Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.

31 March 2020

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PUMA, a potent killer with or without p53

31 March 2020

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Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

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Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

31 March 2020

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Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition

31 March 2020

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Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

31 March 2020

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Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk

31 March 2020

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Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma

31 March 2020

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

31 March 2020

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Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins.

31 March 2020

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

31 March 2020

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Oncogenic shock: turning an activated kinase against the tumor cell.

31 March 2020

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Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

31 March 2020

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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

31 March 2020

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Programmed anuclear cell death delimits platelet life span.

31 March 2020

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Bcl-2 family proteins are essential for platelet survival.

31 March 2020

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

31 March 2020

1 reference

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

31 March 2020

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

31 March 2020

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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

31 March 2020

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Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

31 March 2020

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Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

31 March 2020

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

31 March 2020

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

31 March 2020

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

31 March 2020

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

31 March 2020

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

31 March 2020

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

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Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

31 March 2020

1 reference

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

31 March 2020

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A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival

31 March 2020

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

31 March 2020

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Structure-guided design of a selective BCL-X(L) inhibitor

31 March 2020

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Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency

31 March 2020

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Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition

31 March 2020

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Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

31 March 2020

1 reference

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737

31 March 2020

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Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

31 March 2020

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

31 March 2020

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

31 March 2020

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Shedding light on apoptosis at subcellular membranes

31 March 2020

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

31 March 2020

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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

31 March 2020

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The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria

31 March 2020

1 reference

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

31 March 2020

1 reference

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

31 March 2020

1 reference

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

Nonredundant role of Bax and Bak in Bid-mediated apoptosis

31 March 2020

1 reference

Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

31 March 2020

1 reference

Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis

31 March 2020

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Resistance to caspase-independent cell death requires persistence of intact mitochondria

31 March 2020

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Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

31 March 2020

1 reference

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

31 March 2020

1 reference

Caspase-3-mediated cleavage of Rad9 during apoptosis

31 March 2020

1 reference

Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?

31 March 2020

1 reference

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.

31 March 2020

1 reference

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

31 March 2020

1 reference

Non-apoptotic roles of Bcl-2 family: the calcium connection

31 March 2020

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

1 reference

TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

31 March 2020

1 reference

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

31 March 2020

1 reference

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

31 March 2020

1 reference

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

31 March 2020

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Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

31 March 2020

1 reference

The mitochondrial p53 pathway

31 March 2020

1 reference

A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

31 March 2020

1 reference

Modelling Myc inhibition as a cancer therapy

31 March 2020

1 reference

Mcl-1 is a potential therapeutic target in multiple types of cancer

31 March 2020

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Unique biology of Mcl-1: therapeutic opportunities in cancer

31 March 2020

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Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation

31 March 2020

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mTORC1 promotes survival through translational control of Mcl-1.

31 March 2020

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Targeting Mcl-1 for the therapy of cancer

31 March 2020

1 reference

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

31 March 2020

1 reference

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

31 March 2020

1 reference

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

31 March 2020

1 reference

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

31 March 2020

1 reference

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

31 March 2020

1 reference

N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells.

31 March 2020

1 reference

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

31 March 2020

1 reference

Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration

31 March 2020

1 reference

Regulation of cancer cell survival by BCL2 family members upon prolonged mitotic arrest: opportunities for anticancer therapy

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23783119

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC3538

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Dimensions Publication ID

29 August 2017

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