(Q33427651)

26 July 2017

ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies (English)

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thrombotic thrombocytopenic purpura

26 July 2017

1 reference

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Elien Roose

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hans Deckmyn

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Karen Vanhoorelbeke

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

2

Sebastien Verhenne

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

An-Sofie Schelpe

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Simon F De Meyer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

18 November 2015

1 reference

Expert Review of Hematology

26 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

209-221

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581428%20AND%20SRC:MED&resulttype=core&format=json

Of von Willebrand factor and platelets

7 June 2020

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Conformational activation of ADAMTS13.

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Allosteric activation of ADAMTS13 by von Willebrand factor.

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A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

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The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation

21 January 2018

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Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura

21 January 2018

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Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

21 January 2018

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Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

21 January 2018

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Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

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Imitators of severe pre-eclampsia

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Proteolytic processing of von Willebrand factor by adamts13 and leukocyte proteases

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Inherited ADAMTS13 deficiency (Upshaw-Schulman syndrome): a short review.

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A phenotype-genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom

21 January 2018

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Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura

21 January 2018

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Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes

21 January 2018

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Ten candidate ADAMTS13 mutations in six French families with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).

21 January 2018

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Experiences in a family with the Upshaw-Schulman syndrome over a 44-year period

21 January 2018

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Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry.

21 January 2018

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Registry of 919 patients with thrombotic microangiopathies across Japan: database of Nara Medical University during 1998-2008.

21 January 2018

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Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura

21 January 2018

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IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura

21 January 2018

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Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura.

21 January 2018

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Acquired thrombotic thrombocytopenic purpura. Development of an autoimmune response

21 January 2018

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Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells

21 January 2018

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Acquired TTP: ADAMTS13 meets the immune system

21 January 2018

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Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

21 January 2018

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Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura

21 January 2018

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ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

21 January 2018

1 reference

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ADAMTS-13 activity and autoantibodies classes and subclasses as prognostic predictors in acquired thrombotic thrombocytopenic purpura

21 January 2018

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Survival and relapse in patients with thrombotic thrombocytopenic purpura

21 January 2018

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Prognostic value of inhibitory anti-ADAMTS13 antibodies in adult-acquired thrombotic thrombocytopenic purpura

21 January 2018

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Persistence of circulating ADAMTS13-specific immune complexes in patients with acquired thrombotic thrombocytopenic purpura

21 January 2018

1 reference

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Measurement and prevalence of circulating ADAMTS13-specific immune complexes in autoimmune thrombotic thrombocytopenic purpura.

21 January 2018

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The role of IgM antibodies in the recognition and clearance of apoptotic cells

21 January 2018

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Selective IgG subclass deficiency: quantification and clinical relevance

21 January 2018

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The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions

21 January 2018

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

21 January 2018

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Complement activation in thrombotic thrombocytopenic purpura

21 January 2018

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Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP.

21 January 2018

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Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

21 January 2018

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Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy

21 January 2018

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Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura.

21 January 2018

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Translational applications of antibody phage display

21 January 2018

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VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

21 January 2018

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High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.

21 January 2018

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The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs.

21 January 2018

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21 January 2018

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Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group

21 January 2018

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Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients

21 January 2018

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How I treat patients with thrombotic thrombocytopenic purpura: 2010.

21 January 2018

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A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura

21 January 2018

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Rituximab for thrombotic thrombocytopenic purpura: benefit of early administration during acute episodes and use of prophylaxis to prevent relapse

21 January 2018

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Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.

21 January 2018

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Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

21 January 2018

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Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura

21 January 2018

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The TITAN trial--assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura

21 January 2018

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A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13.

21 January 2018

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Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura

21 January 2018

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Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

21 January 2018

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Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

21 January 2018

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N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

21 January 2018

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Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy

21 January 2018

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Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

21 January 2018

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Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy

21 January 2018

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Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes

21 January 2018

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AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura

21 January 2018

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Recombinant ADAMTS13 normalizes von Willebrand factor-cleaving activity in plasma of acquired TTP patients by overriding inhibitory antibodies.

21 January 2018

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Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report

21 January 2018

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The role of N-acetylcysteine in the treatment of thrombotic thrombocytopenic purpura

21 January 2018

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Long-term safety and efficacy of factor IX gene therapy in hemophilia B.

21 January 2018

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A modified γ-retrovirus vector for X-linked severe combined immunodeficiency

21 January 2018

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Modulation of the von Willebrand factor-dependent platelet adhesion through alternative proteolytic pathways

21 January 2018

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Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

21 January 2018

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Thrombosis: tangled up in NETs

21 January 2018

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Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies

21 January 2018

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Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies.

21 January 2018

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Effects of plasmin on von Willebrand factor multimers. Degradation in vitro and stimulation of release in vivo

21 January 2018

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Different expression of the plasminogen activation system in renal thrombotic microangiopathy and the normal human kidney

21 January 2018

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Proteolytic inactivation of ADAMTS13 by thrombin and plasmin.

21 January 2018

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Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

21 January 2018

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