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Trapping moving targets with small molecules
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
title
Trapping moving targets with small molecules
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
author name string
Gregory M Lee
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
Charles S Craik
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
language of work or name
English
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publication date
1 April 2009
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stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
published in
Science
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stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
volume
324
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
issue
5924
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stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
page(s)
213-215
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Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
cites work
Binding of small-molecule ligands to proteins: "what you see" is not always "what you get".
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Small molecule inhibitors of the p53-MDM2.
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21 June 2018
Allosteric regulation and catalysis emerge via a common route.
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21 June 2018
Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept
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21 June 2018
Simultaneous detection and deconvolution of congested NMR spectra containing three isotopically labeled species
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The current status of the NNRTI family of antiretrovirals used in the HAART regime against HIV infection
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Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.
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21 June 2018
Allostery: absence of a change in shape does not imply that allostery is not at play
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21 June 2018
Antiretroviral therapy : optimal sequencing of therapy to avoid resistance
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21 June 2018
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
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21 June 2018
Dynamic personalities of proteins
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21 June 2018
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
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21 June 2018
Conformational entropy in molecular recognition by proteins
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21 June 2018
Mechanism of coupled folding and binding of an intrinsically disordered protein
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21 June 2018
Targeting structural flexibility in HIV-1 protease inhibitor binding
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21 June 2018
The drug development crisis: efficiency and safety
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21 June 2018
An NMR perspective on enzyme dynamics
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21 June 2018
A common allosteric site and mechanism in caspases
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21 June 2018
Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy
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21 June 2018
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
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21 June 2018
Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain
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21 June 2018
Intrinsically unstructured proteins and their functions
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21 June 2018
Identification of small-molecule antagonists that inhibit an activator: coactivator interaction
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21 June 2018
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
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PubMed Central
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21 June 2018
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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PubMed Central
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21 June 2018
The role of dynamics in allosteric regulation
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PubMed Central
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21 June 2018
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL
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PubMed Central
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21 June 2018
Complexity and simplicity of ligand-macromolecule interactions: the energy landscape perspective
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21 June 2018
Folding and binding cascades: shifts in energy landscapes
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21 June 2018
Folding funnels, binding funnels, and protein function
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21 June 2018
Viral proteases: evolution of diverse structural motifs to optimize function
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21 June 2018
Discovering high-affinity ligands for proteins: SAR by NMR
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PubMed Central
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21 June 2018
Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981433
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21 June 2018
Ligand binding and internal equilibiums in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981433
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21 June 2018
Folding of the KIX domain: characterization of the equilibrium analog of a folding intermediate using 15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981433
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31 October 2018
Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib
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PubMed Central
reference URL
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31 October 2018
Induced structure of a helical switch as a mechanism to regulate enzymatic activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981433
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31 October 2018
Isotopically discriminated NMR spectroscopy: a tool for investigating complex protein interactions in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19359579
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Solution NMR of supramolecular complexes: providing new insights into function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19359579
retrieved
12 December 2020
based on heuristic
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Identifiers
DOI
10.1126/SCIENCE.1169378
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
ADS bibcode
2009Sci...324..213L
0 references
PMCID
2981433
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
PubMed ID
19359579
1 reference
stated in
Europe PubMed Central
PubMed ID
19359579
retrieved
26 July 2017
ResearchGate publication ID
24271161
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