(Q33437371)

26 July 2017

title

Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia (English)

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26 July 2017

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2

Qing-Kai Yang

1 reference

26 July 2017

Run-Qiang Chen

1

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26 July 2017

Yan-Ling Chen

3

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26 July 2017

Vasco A Oliveira

4

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26 July 2017

William S Dalton

5

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26 July 2017

Colleen Fearns

6

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26 July 2017

Jiing-Dwan Lee

7

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26 July 2017

language of work or name

English

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publication date

30 April 2009

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Journal of Biological Chemistry

26 July 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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26 July 2017

volume

284

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26 July 2017

issue

25

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26 July 2017

page(s)

16752-16758

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The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

26 July 2017

cites work

1 reference

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Hypoxia signalling through mTOR and the unfolded protein response in cancer

21 June 2018

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A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans

21 June 2018

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

21 June 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 June 2018

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hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

21 June 2018

1 reference

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A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis

21 June 2018

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

21 June 2018

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21 June 2018

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Defining the role of mTOR in cancer

21 June 2018

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Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

21 June 2018

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Hypoxia-inducible factors, stem cells, and cancer

21 June 2018

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Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay

21 June 2018

1 reference

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Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.

21 June 2018

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

21 June 2018

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PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

21 June 2018

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Hypoxia signalling in cancer and approaches to enforce tumour regression

21 June 2018

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 June 2018

1 reference

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Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK.

21 June 2018

1 reference

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New roles for the LKB1-->AMPK pathway.

21 June 2018

1 reference

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

21 June 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 June 2018

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21 June 2018

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21 June 2018

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Initiating cellular stress responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719310

The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells

21 June 2018

1 reference

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Exploiting tumour hypoxia in cancer treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719310

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 June 2018

1 reference

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Targeting HIF-1 for cancer therapy

21 June 2018

1 reference

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MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719310

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 June 2018

1 reference

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

21 June 2018

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

21 June 2018

1 reference

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Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

21 June 2018

1 reference

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ERK activation upon hypoxia: involvement in HIF-1 activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719310

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

21 June 2018

1 reference

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.014316

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.014316

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.014316

21 January 2018

Identifiers

DOI

10.1074/JBC.M109.014316

1 reference

26 July 2017

1 reference

26 July 2017

1 reference