(Q40184757)

English

Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.

scientific article published on 8 January 2007

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Europe PubMed Central

PubMed publication ID

18 September 2017

Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Jacques Pouysségur

5

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J Pouyssegur

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Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

K M Sutton

1

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Europe PubMed Central

PubMed publication ID

18 September 2017

S Hayat

2

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Europe PubMed Central

PubMed publication ID

18 September 2017

N-M Chau

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

S Cook

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

A Ahmed

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

N Perusinghe

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

R Le Floch

8

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

J Yang

9

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

M Ashcroft

10

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18 September 2017

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publication date

8 January 2007

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Europe PubMed Central

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18 September 2017

1 reference

Europe PubMed Central

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18 September 2017

26

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Europe PubMed Central

PubMed publication ID

18 September 2017

27

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Europe PubMed Central

PubMed publication ID

18 September 2017

3920-3929

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Europe PubMed Central

PubMed publication ID

18 September 2017

CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Hypoxia-inducible factor-1 and oncogenic signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

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21 January 2018

Targeting the molecular basis for tumour hypoxia.

1 reference

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21 January 2018

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

1 reference

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21 January 2018

PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway.

1 reference

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21 January 2018

Guilty as charged: B-RAF is a human oncogene

1 reference

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21 January 2018

Hypoxia--a key regulatory factor in tumour growth

1 reference

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21 January 2018

Biological consequences of tumor hypoxia

1 reference

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21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

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21 January 2018

Oxygen sensors and angiogenesis

1 reference

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21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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21 January 2018

Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis

1 reference

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21 January 2018

HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

ERK activation upon hypoxia: involvement in HIF-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

ERK and calcium in activation of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

1 reference

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21 January 2018

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

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21 January 2018

Hypoxia and drug resistance

1 reference

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21 January 2018

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

21 January 2018

Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy

1 reference

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21 January 2018

Expression of hypoxia-inducible factor 1? in brain tumors

1 reference

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21 January 2018

Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210168

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1210168

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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