(Q33442896)

26 July 2017

title

Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data (English)

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26 July 2017

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2

Walter S Woltosz

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26 July 2017

Viera Lukacova

1

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26 July 2017

Michael B Bolger

series ordinal

3

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26 July 2017

language of work or name

English

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publication date

9 May 2009

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26 July 2017

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26 July 2017

volume

11

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26 July 2017

issue

2

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26 July 2017

page(s)

323-334

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Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds

26 July 2017

cites work

1 reference

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In vitro - in vivo correlation: from theory to applications

21 June 2018

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A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

21 June 2018

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21 June 2018

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 June 2018

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Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

21 June 2018

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The composite solubility versus pH profile and its role in intestinal absorption prediction

21 June 2018

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21 June 2018

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

21 June 2018

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Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption

21 June 2018

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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 June 2018

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Psychomotor and memory effects of two adinazolam formulations assessed by a computerized neuropsychological test battery.

21 June 2018

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Comparison of the spectrum of cognitive effects of alprazolam and adinazolam after single doses in healthy subjects

21 June 2018

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Pharmacokinetic absorption plots from oral data alone or oral/intravenous data and an exact Loo-Riegelman equation

21 June 2018

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Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.

21 June 2018

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Wagner's exact Loo-Riegelman equation: the need for a criterion to choose between the linear and logarithmic trapezoidal rule.

21 June 2018

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Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon

21 June 2018

1 reference

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Adinazolam--a new antidepressant: findings of a placebo-controlled, double-blind study in outpatients with major depression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by triazolobenzodiazepines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Adinazolam pharmacokinetics and behavioral effects following administration of 20-60 mg oral doses of its mesylate salt in healthy volunteers.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Comparison of adinazolam pharmacokinetics and effects in healthy and cirrhotic subjects.

21 June 2018

1 reference

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Ranitidine does not alter adinazolam pharmacokinetics or pharmacodynamics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Bioavailability assessment: methods to estimate total area (AUC O to infinity) and total amount excreted (A infinity e) and importance of blood and urine sampling scheme with application to digoxin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Possible involvement of GABA in the central actions of benzodiazepines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

A comparison of the prediction accuracy of two IVIVC modelling techniques.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: I. Principles and some general algorithms.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

In vitro to in vivo extrapolation for trichloroethylene metabolism in humans.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Novel approach to the analysis of in vitro-in vivo relationships.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Development of in vitro Vmax and Km values for the metabolism of isofenphos by P-450 liver enzymes in animals and human

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Adinazolam-SR in panic disorder with agoraphobia: relationship of daily dose to efficacy.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Effects of adinazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691467

Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide

31 October 2018

1 reference

12 December 2020

Development of clinical dosage forms for a poorly water soluble drug I: Application of polyethylene glycol-polysorbate 80 solid dispersion carrier system

1 reference

12 December 2020

Determination of drug metabolizing enzymes in needle biopsies of human liver

1 reference

12 December 2020

Plasma Concentrations and Beta-Blocking Effects in Normal Volunteers After Intravenous Doses of Metoprolol and Propranolol

1 reference

12 December 2020

Effects of different buffer species on partition coefficients of drugs used in quantitative structure-activity relationships

1 reference

12 December 2020

Physicochemical properties of the nucleoside prodrug R1626 leading to high oral bioavailability

1 reference

12 December 2020

Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individuals

1 reference

12 December 2020

Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment

1 reference

12 December 2020

Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers

1 reference

12 December 2020

Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate following single intravenous infusions of each compound in health volunteers

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic comparison of immediate-release and sustained-release adinazolam mesylate tablets after single- and multiple-dose administration

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of adinazolam and N-desmethyladinazolam after oral and intravenous dosing in healthy young and elderly volunteers

1 reference

12 December 2020

Draft guidance for industry extended-release solid oral dosage forms. Development, evaluation and application of in vitro-in vivo correlations

1 reference

12 December 2020

Development and internal validation of an in vitro-in vivo correlation for a hydrophilic metoprolol tartrate extended release tablet formulation

1 reference

12 December 2020

Development of metoprolol tartrate extended-release matrix tablet formulations for regulatory policy consideration

1 reference

12 December 2020

Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines

1 reference

12 December 2020

10.1208/S12248-009-9107-2

Identifiers

DOI

1 reference

Dimensions Publication ID

26 July 2017

1021565403

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Fatcat ID

release_djo2mmhswzhzlnxiewgm56esqu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/djo2mmhswzhzlnxiewgm56esqu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2691467

1 reference

26 July 2017

1 reference