(Q33467104)

27 July 2017

title

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts (English)

1 reference

27 July 2017

0 references

10

Eric Boerwinkle

0 references

Cora E Lewis

5

object named as

Cora E Lewis

1 reference

27 July 2017

8

Thomas H Mosley

1 reference

27 July 2017

2

Myriam Fornage

1 reference

27 July 2017

Len A Pennacchio

9

1 reference

ORCID Public Data File 2021

author name string

Jan Bressler

1

1 reference

27 July 2017

Craig L Hanis

3

1 reference

27 July 2017

Wen Hong Linda Kao

4

1 reference

27 July 2017

Ruth McPherson

6

1 reference

27 July 2017

Robert Dent

7

1 reference

27 July 2017

publication date

12 June 2009

1 reference

27 July 2017

1 reference

27 July 2017

volume

10

1 reference

27 July 2017

page(s)

56

1 reference

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

27 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Common variants near MC4R are associated with fat mass, weight and risk of obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Variation in FTO contributes to childhood obesity and severe adult obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Medical sequencing at the extremes of human body mass

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Comment on "A common genetic variant is associated with adult and childhood obesity"

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Prevalence of overweight and obesity in the United States, 1999-2004

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

A haplotype map of the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Modern science versus the stigma of obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Prevalence and Trends in Obesity Among US Adults, 1999-2000

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Obesity: preventing and managing the global epidemic. Report of a WHO consultation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Regulation of gene expression by SREBP and SCAP.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

An Adoption Study of Human Obesity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

CARDIA: study design, recruitment, and some characteristics of the examined subjects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Diabetes, gallbladder disease, obesity, and hypertension among Hispanics in New Mexico

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Regulation of the mevalonate pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Cardiovascular risk factors in young adults. The CARDIA baseline monograph.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

The disease burden associated with overweight and obesity

21 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

A twin study of human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

A common genetic variant is associated with adult and childhood obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

A common polymorphism is associated with body mass index in Uyghur population

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

No association between rs7566605 variant and being overweight in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Contribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

The Body-Mass Index of Twins Who Have Been Reared Apart

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-10-56

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706232

Familial aggregation of hypertension treatment and control in the Genetic Epidemiology Network of Arteriopathy (GENOA) study

31 October 2018

1 reference

12 December 2020

Body mass index and mortality among nonsmoking older persons. The Framingham Heart Study

1 reference

12 December 2020

Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study

1 reference

12 December 2020

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2350-10-56

1 reference

Dimensions Publication ID

27 July 2017

0 references

1 reference

27 July 2017

1 reference