(Q33474085)

English

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 July 2017

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

0 references

spinocerebellar ataxia

1 reference

based on heuristic

inferred from title

muscular dystrophy

1 reference

based on heuristic

inferred from title

Krzysztof Sobczak

4

object named as

Krzysztof Sobczak

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Alexei Pushechnikov

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Melissa M Lee

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Jessica L Childs-Disney

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Jonathan M French

5

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Charles A Thornton

6

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Matthew D Disney

7

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Europe PubMed Central

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27 July 2017

language of work or name

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publication date

1 July 2009

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Europe PubMed Central

PubMed publication ID

27 July 2017

Journal of the American Chemical Society

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Europe PubMed Central

PubMed publication ID

27 July 2017

131

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Europe PubMed Central

PubMed publication ID

27 July 2017

28

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

9767-9779

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

A small molecule microarray platform to select RNA internal loop-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Trinucleotide Repeat Disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Noncoding RNAs and intranuclear positioning in monoallelic gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Improved nuclear localization of DNA-binding polyamides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Carbodiimide-based benzimidazole library method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

MicroRNAs and chromosomal abnormalities in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Detection of non-coding RNAs on the basis of predicted secondary structure formation free energy change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

The structural basis of myotonic dystrophy from the crystal structure of CUG repeats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

A high-throughput assay for assessing the cell permeability of combinatorial libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

RNA pathogenesis of the myotonic dystrophies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Polytriazoles as copper(I)-stabilizing ligands in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Insulin receptor splicing alteration in myotonic dystrophy type 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

A muscleblind knockout model for myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Genetic control by a metabolite binding mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

RNAMotif, an RNA secondary structure definition and search algorithm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

An extensive class of small RNAs in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Molecular recognition of DNA by small molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Initial sequencing and analysis of the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

The Sequence of the Human Genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Synthesis of fluorescent microgonotropens (FMGTs) and their interactions with dsDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Site-directed ligand discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Specific binding of Hoechst 33258 to site 1 thymidylate synthase mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731475

14 July 2018

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microwave-assisted solid-phase synthesis of peptoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major groove accessibility of RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CUG repeats present in myotonin kinase RNA form metastable "slippery" hairpins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic ligands point to cell surface strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nearest-neighbor thermodynamics and NMR of DNA sequences with internal A.A, C.C, G.G, and T.T mismatches

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Click to fit: versatile polyvalent display on a peptidomimetic scaffold

1 reference

https://pubmed.ncbi.nlm.nih.gov/19552411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA9020149

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

0 references

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