(Q33480387)

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Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action

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Europe PubMed Central

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27 July 2017

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Europe PubMed Central

Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action (English)

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Europe PubMed Central

PubMed publication ID

27 July 2017

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James Bus

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Europe PubMed Central

PubMed publication ID

27 July 2017

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George Cruzan

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Europe PubMed Central

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27 July 2017

Marcy Banton

3

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Europe PubMed Central

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27 July 2017

Ralph Gingell

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Europe PubMed Central

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27 July 2017

Gary Carlson

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27 July 2017

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7 July 2009

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Europe PubMed Central

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27 July 2017

Regulatory Toxicology and Pharmacology

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Europe PubMed Central

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27 July 2017

55

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Europe PubMed Central

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27 July 2017

2

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Europe PubMed Central

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27 July 2017

205-218

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Europe PubMed Central

PubMed publication ID

27 July 2017

Lack of effect of coumarin on the formation of micronuclei in an in vivo mouse micronucleus assay

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Lack of effect of coumarin on unscheduled DNA synthesis in precision-cut human liver slices

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Lymphocyte phenotype analysis and chromosome aberration frequency of workers occupationally exposed to styrene, benzene, polycyclic aromatic hydrocarbons or mixed solvents

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Is human exposure to styrene a cause of cytogenetic damage? A re-analysis of the available evidence.

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IPCS framework for analyzing the relevance of a cancer mode of action for humans.

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Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation

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Selective Clara cell injury in mouse lung following acute administration of coumarin

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Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation

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A study of tobacco carcinogenesis. XLVII. Bioassays of vinylpyridines for genotoxicity and for tumorigenicity in A/J mice

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Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice

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Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes

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4-Vinylphenol-induced pneumotoxicity and hepatotoxicity in mice

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Effect of the inhibition of the metabolism of 4-vinylphenol on its hepatotoxicity and pneumotoxicity in rats and mice

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Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice

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A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene

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4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans.

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Subchronic inhalation studies of styrene in CD rats and CD-1 mice

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Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks

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Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites

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Ring-oxidized metabolites of styrene contribute to styrene-induced Clara-cell toxicity in mice

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Genetic toxicology testing of 41 industrial chemicals

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Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action.

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Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay

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A safety assessment of coumarin taking into account species-specificity of toxicokinetics

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Screening of tobacco smoke constituents for mutagenicity using the Ames' test.

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Transformation of cell cultures as an indication of the carcinogenic potential of chemicals

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Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals

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Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs

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U.S. EPA's IRIS assessment of 2-butoxyethanol: the relationship of noncancer to cancer effects

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Pulmonary toxicity and carcinogenicity of trichloroethylene: species differences and modes of action

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The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans

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The role of cytochromes P-450 in styrene induced pulmonary toxicity and carcinogenicity

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Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers

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Co-mutagenicity of coumarin (1,2-benzopyrone) with aflatoxin B1 and human liver S9 in mammalian cells

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Mode of action frameworks: a critical analysis

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Evidence-based toxicology: a comprehensive framework for causation

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The influence of simple aromatics on benzene clastogenicity

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Use of historical control data in carcinogenicity studies in rodents

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Review of the genotoxicity of styrene in humans

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Styrene-7,8-oxide burden in ventilated, perfused lungs of mice and rats exposed to vaporous styrene

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Effects of styrene and its metabolites on different lung compartments of the mouse--cell proliferation and histomorphology

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PPARalpha agonist-induced rodent tumors: modes of action and human relevance

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Styrene-7,8-oxide in blood of workers exposed to styrene

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Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene

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Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment

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Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS Human Framework for the Analysis of a cancer mode of action for humans

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Effects of ethylbenzene, toluene, and xylene on the induction of micronuclei in bone marrow polychromatic erythrocytes of mice

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10.1016/J.YRTPH.2009.07.002

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

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