(Q33500359)

27 July 2017

title

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605. (English)

1 reference

27 July 2017

William N Pappano

1

1 reference

27 July 2017

Paul M Jung

2

1 reference

27 July 2017

Jonathan A Meulbroek

3

1 reference

27 July 2017

Yi-Chun Wang

4

1 reference

27 July 2017

Robert D Hubbard

5

1 reference

27 July 2017

Qian Zhang

6

1 reference

27 July 2017

Meagan M Grudzien

7

1 reference

27 July 2017

Niru B Soni

8

1 reference

27 July 2017

Eric F Johnson

9

1 reference

27 July 2017

George S Sheppard

10

1 reference

27 July 2017

Cherrie Donawho

11

1 reference

27 July 2017

Fritz G Buchanan

12

1 reference

27 July 2017

Steven K Davidsen

13

1 reference

27 July 2017

Randy L Bell

14

1 reference

27 July 2017

Jieyi Wang

15

1 reference

27 July 2017

language of work or name

English

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publication date

4 September 2009

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27 July 2017

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27 July 2017

volume

9

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27 July 2017

page(s)

314

1 reference

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

27 July 2017

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21 June 2018

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

21 June 2018

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Mechanisms of resistance to ErbB-targeted cancer therapeutics

21 June 2018

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Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation

21 June 2018

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Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors

21 June 2018

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Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

21 June 2018

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Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling.

21 June 2018

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

21 June 2018

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

21 June 2018

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21 June 2018

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Molecular interactions of the IGF system

21 June 2018

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The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

21 June 2018

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Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.

21 June 2018

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Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells

21 June 2018

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Insulin-like growth factors and neoplasia.

21 June 2018

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A systematic review of molecular and biological tumor markers in neuroblastoma

21 June 2018

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A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

21 June 2018

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

21 June 2018

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The insulin-like growth factor system and cancer

21 June 2018

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Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 June 2018

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

21 June 2018

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The effects of insulin-like growth factors on tumorigenesis and neoplastic growth

21 June 2018

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 June 2018

1 reference

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Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP sec

21 June 2018

1 reference

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Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase

21 June 2018

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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

21 June 2018

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Unraveling resistance to trastuzumab (Herceptin): insulin-like growth factor-I receptor, a new suspect.

21 June 2018

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Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

21 January 2018

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Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

21 January 2018

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Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).

21 January 2018

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Rosetta error model for gene expression analysis

21 January 2018

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TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis

21 January 2018

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Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

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An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation

21 January 2018

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Loss of imprinting of the IGF-II and H19 genes in epithelial ovarian cancer.

31 October 2018

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Loss of IGF2 imprinting: a potential marker of colorectal cancer risk

31 October 2018

1 reference

PubMed

12 December 2020

Covalent association between human thymus leukemia-like antigens and CD8(Tp32) molecules

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PubMed

12 December 2020

Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-9-314

1 reference

Dimensions Publication ID

27 July 2017

0 references

1 reference

27 July 2017

1 reference