(Q33508944)

27 July 2017

The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors (English)

1 reference

27 July 2017

1 reference

2

Ian F Tannock

1 reference

27 July 2017

Krupa J Patel

1

1 reference

PubMed ID

19807929

27 July 2017

language of work or name

English

0 references

publication date

6 October 2009

1 reference

27 July 2017

1 reference

27 July 2017

9

1 reference

27 July 2017

356

1 reference

Creative Commons Attribution 2.0 Generic

27 July 2017

start time

6 October 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1471-2407-9-356

0 references

cites work

Prediction of drug response in breast cancer using integrative experimental/computational modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Towards whole-organ modelling of tumour growth.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Effect of valspodar on the pharmacokinetics of unbound paclitaxel

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Repopulation of tumour cells between cycles of chemotherapy: a neglected factor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Multidrug resistance in cancer: role of ATP-dependent transporters

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar).

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Doxorubicin gradients in human breast cancer.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Clinical trials of P-glycoprotein reversal in solid tumours

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

P-glycoprotein, multidrug resistance and tumor progression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Aspects of cytotoxic drug penetration, with particular reference to anthracyclines

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

P-glycoprotein: multidrug-resistance and a superfamily of membrane-associated transport proteins.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Charles F. Kettering Prize. P-glycoprotein and resistance to anticancer drugs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

14 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug-resistant solid tumors by co-administering valspodar (PSC 833) with sterically stabilized liposomal doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Microregional effects of gemcitabine in HCT-116 xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Identification of two distinct intracellular sites that contribute to the modulation of multidrug resistance in P388/ADR cells expressing P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

A pilot phase II trial of valspodar modulation of multidrug resistance to paclitaxel in the treatment of metastatic carcinoma of the breast (E1195): a trial of the Eastern Cooperative Oncology Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-9-356

Repopulation in murine breast tumors during and after sequential treatments with cyclophosphamide and 5-fluorouracil

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

A dose-finding and pharmacokinetic study of reversal of multidrug resistance with SDZ PSC 833 in combination with doxorubicin in patients with solid tumors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770566

Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma

31 October 2018

1 reference

12 December 2020

Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures

1 reference

12 December 2020

Expression of a multidrug resistance gene in human cancers

1 reference

12 December 2020

Intracellular uptake and cytotoxic effect in vitro of doxorubicin and epirubicin in human leukemic and normal hematopoietic cells

1 reference

12 December 2020

Dynamics of tumor cell clonogen repopulation in a murine sarcoma treated with cyclophosphamide

1 reference

12 December 2020

Pharmacokinetic/cytokinetic principles in the chemotherapy of solid tumours

1 reference

12 December 2020

Liposomal doxorubicin circumvents PSC 833-free drug interactions, resulting in effective therapy of multidrug-resistant solid tumors

1 reference

12 December 2020

Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids

1 reference

12 December 2020

Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-9-356

1 reference

PubMed ID

19807929

Dimensions Publication ID

27 July 2017

0 references

1 reference

27 July 2017

1 reference

PubMed ID

19807929