(Q33569870)

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MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

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scholarly article

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Europe PubMed Central

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28 July 2017

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Amy G Hise

10

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Richard M Ransohoff

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Richard M Ransohoff

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28 July 2017

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Minjia Yu

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28 July 2017

Hao Zhou

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28 July 2017

Junjie Zhao

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28 July 2017

Nengming Xiao

4

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28 July 2017

Sanjoy Roychowdhury

5

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28 July 2017

David Schmitt

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28 July 2017

Bingqing Hu

7

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28 July 2017

Clifford V Harding

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28 July 2017

Stanley L Hazen

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28 July 2017

Anthony L DeFranco

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28 July 2017

Paul L Fox

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28 July 2017

Richard E Morton

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28 July 2017

Paul E Dicorleto

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28 July 2017

Maria Febbraio

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28 July 2017

Laura E Nagy

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28 July 2017

Jonathan D Smith

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28 July 2017

Jian-an Wang

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Xiaoxia Li

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21 April 2014

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28 July 2017

Journal of Experimental Medicine

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28 July 2017

211

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28 July 2017

5

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28 July 2017

887-907

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28 July 2017

Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs.

1 reference

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The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice

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Inflammation as a Link between Obesity and Metabolic Syndrome

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CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity

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AIMing at metabolic syndrome. -Towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM).-.

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Macrophage polarization in metabolic disorders: functions and regulation

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CD14 modulates inflammation-driven insulin resistance

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The Dynamics of Oxidized LDL during Atherogenesis

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Adipose tissue remodeling and obesity

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Toll-like receptors, inflammation, metabolism and obesity.

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Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4.

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Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.

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What the Myddosome structure tells us about the initiation of innate immunity

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21 June 2018

Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice

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21 June 2018

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

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Epidemiology of the metabolic syndrome in the USA

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Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

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TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

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21 June 2018

Toll-like receptors: linking inflammation to metabolism

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21 June 2018

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

1 reference

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21 June 2018

Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice

1 reference

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21 June 2018

Chronic inflammation in obesity and the metabolic syndrome

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21 June 2018

Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production.

1 reference

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21 June 2018

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

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21 June 2018

Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis

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21 June 2018

Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice

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21 June 2018

Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype

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21 June 2018

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis

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21 June 2018

Tlr2 is critical for diet-induced metabolic syndrome in a murine model.

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21 June 2018

GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

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21 June 2018

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

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IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

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Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis

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Lipolysis and lipid mobilization in human adipose tissue

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21 June 2018

The role of GM-CSF in adipose tissue inflammation.

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Signalling adaptors used by Toll-like receptors: an update.

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Colony-stimulating factors in inflammation and autoimmunity.

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Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome

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Heterogeneity of human macrophages in culture and in atherosclerotic plaques

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21 June 2018

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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21 June 2018

Adipose tissue macrophages.

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21 June 2018

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

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Metabolic endotoxemia initiates obesity and insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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21 June 2018

Inflammation and metabolic disorders

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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression

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Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway

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Colony-stimulating factor-1 in immunity and inflammation.

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Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.

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21 June 2018

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

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21 June 2018

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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21 June 2018

Obesity is associated with macrophage accumulation in adipose tissue

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21 June 2018

Endothelial cells require STAT3 for protection against endotoxin-induced inflammation

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21 June 2018

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

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21 June 2018

Increased Production of 12/15 Lipoxygenase Eicosanoids Accelerates Monocyte/Endothelial Interactions in Diabetic db/db Mice

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21 June 2018

MyD88 as a bottle neck in Toll/IL-1 signaling

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21 June 2018

A central role for JNK in obesity and insulin resistance

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21 June 2018

Cardiovascular biology: a cholesterol tether

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21 June 2018

Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma

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21 June 2018

Association between myeloperoxidase levels and risk of coronary artery disease

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21 June 2018

PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice

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21 June 2018

Nitric oxide is a physiological substrate for mammalian peroxidases

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21 June 2018

Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice

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21 June 2018

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

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21 June 2018

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Interleukin-6 exacerbates early atherosclerosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Mechanism of increase in basal lipolysis of enlarged adipocytes in obese animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

21 June 2018

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: implication in atherosclerosis

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Elevated serum C-reactive protein levels and advanced atherosclerosis in youth

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010914

31 October 2018

Toll-like Receptor 4 Polymorphisms and Atherogenesis

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131314

21 January 2018

Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide modulates the catalytic activity of myeloperoxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Productionin Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose tissue inflammation in obesity and metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24752299

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20131314

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

0 references

Sitelinks

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