(Q33664738)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

main subject

cytotoxicity

0 references

Clostridium perfringens

object named as

Clostridium perfringens

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Michelle Lewis

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Charles David Weaver

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

publication date

1 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

page(s)

1825-1847

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 February 2020

copyright license

start time

9 July 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Dominant-negative inhibitors of the Clostridium perfringens epsilon-toxin.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

ChemBank: a small-molecule screening and cheminformatics resource database

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Identification and characterization of small molecules that inhibit intracellular toxin transport

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Hit discovery and hit-to-lead approaches

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Isolation of Clostridium perfringens Type D from a Case of Gas Gangrene.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Statistical practice in high-throughput screening data analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Database resources of the National Center for Biotechnology Information

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Evaluation of inhibitory potencies for compounds inhibiting P-glycoprotein but without maximum effects: f2 values

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Identification of small molecule inhibitors of anthrax lethal factor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Improved statistical methods for hit selection in high-throughput screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarized MDCK cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Cleavage of a C-terminal peptide is essential for heptamerization of Clostridium perfringens epsilon-toxin in the synaptosomal membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Assembly of Clostridium perfringens epsilon-toxin on MDCK cell membrane.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Lambda-toxin of Clostridium perfringens activates the precursor of epsilon-toxin by releasing its N- and C-terminal peptides

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Assessment of aspects of the toxicity of Clostridium perfringens epsilon-toxin using the MDCK cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Evaluation of a new cytotoxicity assay for Clostridium perfringens type D epsilon toxin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Bacterial toxins: a table of lethal amounts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Effect of epsilon toxin-GFP on MDCK cells and renal tubules in vivo

28 July 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Poor solubility limiting significance of in-vitro studies with HIV protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Binding of epsilon-toxin from Clostridium perfringens in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Passive antibody administration (immediate immunity) as a specific defense against biological weapons

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Cross-inhibition between furin and lethal factor inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS2071825

Development of monoclonal antibodies suitable for use in antigen quantification potency tests for clostridial veterinary vaccines

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922765

Variability of serum antibody responses of goat kids to a commercial Clostridium perfringens epsilon toxoid vaccine

30 October 2018

1 reference

12 December 2020

Clostridium welchii epsilon toxin in the intestinal contents of man

1 reference

12 December 2020

The passive protection of lambs against Clostridium perfringens type D with semi-purified hyperimmune serum

1 reference

12 December 2020

Recovery of Clostridium welchii type D from man

1 reference

12 December 2020

Identifiers

DOI

10.3390/TOXINS2071825

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20721308%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference