(Q33680168)

28 July 2017

title

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine (English)

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28 July 2017

5

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28 July 2017

Dominique Guianvarc'h

object named as

Dominique Guianvarc'h

2

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Paola B Arimondo

7

object named as

Paola B Arimondo

1 reference

Catherine Sénamaud-Beaufort

28 July 2017

3

object named as

Catherine Sénamaud-Beaufort

1 reference

28 July 2017

4

Renata Z Jurkowska

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28 July 2017

Christine Champion

1

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28 July 2017

Loïc Ponger

6

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28 July 2017

Anne-Laure Guieysse-Peugeot

8

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28 July 2017

language of work or name

English

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publication date

24 August 2010

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28 July 2017

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28 July 2017

volume

5

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28 July 2017

issue

8

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28 July 2017

page(s)

e12388

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Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

24 August 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

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The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

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Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells

21 June 2018

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Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine

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Zebularine: a new drug for epigenetic therapy

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Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

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DNA methylation in cancer: too much, but also too little

21 June 2018

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Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases

21 June 2018

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21 June 2018

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DNA methylation: past, present and future directions

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Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

21 June 2018

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The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

21 June 2018

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Determination of the order of substrate addition to MspI DNA methyltransferase using a novel mechanism-based inhibitor

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

21 June 2018

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Altering gene expression with 5-azacytidine

21 June 2018

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Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.

21 June 2018

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Binding of the EcoRII methyltransferase to 5-fluorocytosine-containing DNA. Isolation of a bound peptide

21 June 2018

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Kinetics and Mechanisms of Degradation of the Antileukemic Agent 5‐Azacytidine in Aqueous Solutions

21 June 2018

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Methods for the design and analysis of oligodeoxynucleotide-based DNA (cytosine-5) methyltransferase inhibitors

21 June 2018

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The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

21 January 2018

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Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012388

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012388

Angiostatic activity of DNA methyltransferase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012388

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012388

Mutagenicity of the cytidine analog zebularine in Escherichia coli

21 January 2018

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A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).

21 January 2018

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Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme

21 January 2018

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Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. Karn

21 January 2018

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12 December 2020

High-performance Liquid Chromatographic Analysis of Chemical Stability of 5-aza-2′-Deoxycytidine

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12 December 2020

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

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Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA

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12 December 2020

Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase

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12 December 2020

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12 December 2020

10.1371/JOURNAL.PONE.0012388

Identifiers

DOI

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28 July 2017

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28 July 2017

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