(Q33707706)

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Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

neurodegeneration

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based on heuristic

inferred from title

author name string

Latha Devi

1

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Europe PubMed Central

PubMed publication ID

28 July 2017

Masuo Ohno

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

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publication date

23 September 2010

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Europe PubMed Central

PubMed publication ID

28 July 2017

5

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Europe PubMed Central

PubMed publication ID

28 July 2017

9

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Europe PubMed Central

PubMed publication ID

28 July 2017

e12974

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Creative Commons Attribution 4.0 International

23 September 2010

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April 2022 Public Data File from Crossref

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The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

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Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

1 reference

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Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice

1 reference

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21 June 2018

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice

1 reference

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BACE1 and BACE2 enzymatic activities in Alzheimer's disease

1 reference

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Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

1 reference

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beta-Secretase as a therapeutic target for Alzheimer's disease

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

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The Alzheimer's disease beta-secretase enzyme, BACE1.

1 reference

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

1 reference

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Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization

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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

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Genetic and pharmacological basis for therapeutic inhibition of beta- and gamma-secretases in mouse models of Alzheimer's memory deficits.

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice.

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Human beta-secretase (BACE) and BACE inhibitors: progress report

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30 October 2018

Identifiers

10.1371/JOURNAL.PONE.0012974

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

2010PLoSO...512974D

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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