(Q37416750)

20 August 2017

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title

Cell biology, regulation and inhibition of beta-secretase (BACE-1). (English)

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20 August 2017

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Clare E Hunt

1

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20 August 2017

Anthony J Turner

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

1 April 2009

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20 August 2017

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20 August 2017

volume

276

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20 August 2017

issue

7

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20 August 2017

page(s)

1845-1859

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Cellular mechanisms of beta-amyloid production and secretion

20 August 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Why does beta-secretase zymogen possess catalytic activity? Molecular modeling and molecular dynamics simulation studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Amyloid precursor protein and BACE function as oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Targeting of membrane proteins to endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Extracellular release of BACE1 holoproteins from human neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Shedding light on ADAM metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Membrane protein secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A fluid connection: cholesterol and Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Neuronal membrane cholesterol loss enhances amyloid peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The risk of dementia in relation to statins and other lipid lowering agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Regulation of proBACE1 by glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

A new take on prions: preventing Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Hypoxia and reoxygenation increased BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Translational control of BACE1 may go awry in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Structural evidence for gene duplication in the evolution of the acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The search for drug leads targeted to the beta-secretase: an example of the roles of computer assisted approaches in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.06929.X

10.1111/J.1742-4658.2009.06929.X

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference