(Q48366230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Cora O'Neill

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Rivka Ravid

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

language of work or name

English

0 references

publication date

13 November 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

580

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

issue

28-29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

6550-6560

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17113083%20AND%20SRC:MED&resulttype=core&format=json

Beta-secretase (BACE) as a drug target for Alzheimer's disease

22 December 2019

cites work

1 reference

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

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Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

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BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

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A non-amyloidogenic function of BACE-2 in the secretory pathway

21 January 2018

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BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

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Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay.

21 January 2018

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

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21 January 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

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Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls

21 January 2018

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BACE-2 is overexpressed in Down's syndrome.

21 January 2018

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Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

21 January 2018

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Increased beta-secretase activity and expression in rats following transient cerebral ischemia

21 January 2018

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

21 January 2018

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21 January 2018

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Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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