(Q33728087)

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The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate

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Europe PubMed Central

PubMed publication ID

28 July 2017

The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Jeffrey Stein

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Wieslawa M Milewski

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

Arunangsu Dey

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

publication date

29 July 2013

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Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

5

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Europe PubMed Central

PubMed publication ID

28 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

156-169

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

RETRACTED: Betatrophin: a hormone that controls pancreatic β cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

β-cell mass and turnover in humans: effects of obesity and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Formation of a human β-cell population within pancreatic islets is set early in life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Pancreatic beta cells in very old mice retain capacity for compensatory proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

In vitro proliferation of adult human beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Regulated and reversible induction of adult human β-cell replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Skp2 is required for incretin hormone-mediated β-cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Gastrointestinal hormones and the regulation of β-cell mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Serotonin regulates pancreatic beta cell mass during pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Growth factor control of pancreatic islet regeneration and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Expression of the GLP-1 receptor in mouse, rat, and human pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Control of pancreatic beta-cell fate by insulin signaling: The sweet spot hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Recovery from diabetes in mice by beta cell regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

p27Kip1 metabolism: a fascinating labyrinth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Glycogen synthase kinase-3 phosphorylates and regulates the stability of p27kip1 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Growth factors and beta cell replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

cAMP-induced degradation of cyclin D3 through association with GSK-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

The renaissance of GSK3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

A morphological study of the endocrine pancreas in human pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

14 July 2018

Regulated beta-cell regeneration in the adult mouse pancreas.

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https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

Multiple mechanisms for p27(Kip1) translocation and degradation.

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation.

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

p27 Regulates the transition of beta-cells from quiescence to proliferation

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

1 reference

https://api.crossref.org/works/10.4161%2FISL.25605

21 January 2018

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4049839

30 October 2018

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23896637

12 December 2020

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10.4161/ISL.25605

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Europe PubMed Central

PubMed publication ID

28 July 2017

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24 November 2022

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Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

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Europe PubMed Central

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28 July 2017

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