(Q44602874)

4 December 2017

Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice (English)

1 reference

4 December 2017

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice (English)

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

16 March 2024

1 reference

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

16 March 2024

7

C Ronald Kahn

1 reference

4 December 2017

5

Kohjiro Ueki

1 reference

4 December 2017

6

Markus Stoffel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14519599

16 March 2024

author name string

Kenichi Otani

1

1 reference

4 December 2017

Jan Krutzfeldt

4

1 reference

4 December 2017

Rohit N. Kulkarni

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14519599

16 March 2024

Aaron C. Baldwin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14519599

16 March 2024

Kenneth S. Polonsky

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14519599

16 March 2024

language of work or name

1 reference

30 September 2003

1 reference

full work available at URL

4 December 2017

https://www.physiology.org/doi/pdf/10.1152/ajpendo.00533.2001

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

American Journal of Physiology - Endocrinology and Metabolism

16 March 2024

published in

1 reference

4 December 2017

286

1 reference

4 December 2017

1

1 reference

4 December 2017

E41-9

1 reference

Pyridine Nucleotides in Pancreatic Islets During Inhibition of Insulin Release by Exogenous Insulin12

4 December 2017

1

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

16 March 2024

2

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways.

16 March 2024

3

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells

16 March 2024

5

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

16 March 2024

6

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

16 March 2024

7

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

16 March 2024

8

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Muscarinic stimulation exerts both stimulatory and inhibitory effects on the concentration of cytoplasmic Ca2+ in the electrically excitable pancreatic B-cell

16 March 2024

9

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

An inhibitory role for phosphatidylinositol 3-kinase in insulin secretion from pancreatic B cell line MIN6.

16 March 2024

10

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

16 March 2024

11

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

16 March 2024

12

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

16 March 2024

13

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

16 March 2024

15

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

16 March 2024

16

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

16 March 2024

17

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

16 March 2024

18

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

A simple, rapid, and sensitive DNA assay procedure

16 March 2024

19

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

16 March 2024

20

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation

16 March 2024

21

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions

16 March 2024

22

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

16 March 2024

23

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription

16 March 2024

24

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

16 March 2024

25

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin does not mediate glucose stimulation of proinsulin biosynthesis

16 March 2024

26

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

16 March 2024

27

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

16 March 2024

28

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

16 March 2024

29

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

16 March 2024

30

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

16 March 2024

31

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

16 March 2024

32

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

16 March 2024

33

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator

16 March 2024

34

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research

16 March 2024

35

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Growth hormone receptor signalling

16 March 2024

36

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Molecular mechanisms for the control of translation by insulin

16 March 2024

38

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin

16 March 2024

39

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Thapsigargin inhibits the glucose-induced decrease of intracellular Ca2+ in mouse islets of Langerhans

16 March 2024

40

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat

16 March 2024

41

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication

16 March 2024

43

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Disruption of IRS-2 causes type 2 diabetes in mice

16 March 2024

44

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

16 March 2024

45

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

16 March 2024

46

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation

16 March 2024

47

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Insulin regulation of beta-cell function involves a feedback loop on SERCA gene expression, Ca(2+) homeostasis, and insulin expression and secretion

16 March 2024

48

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

16 March 2024

49

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion

16 March 2024

51

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00533.2001

16 March 2024

Identifiers

1 reference

4 December 2017

1 reference