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Molecular population genetics of PCSK9: a signature of recent positive selection.
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Europe PubMed Central
PMC publication ID
2842919
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
title
Molecular population genetics of PCSK9: a signature of recent positive selection
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
main subject
population genetics
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inferred from title
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Keyue Ding
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1
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Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
Iftikhar J Kullo
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object named as
Iftikhar J Kullo
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Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
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3 January 2020
publication date
1 March 2008
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Europe PubMed Central
PMC publication ID
2842919
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retrieved
3 January 2020
published in
Pharmacogenetics and Genomics
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PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
volume
18
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Europe PubMed Central
PMC publication ID
2842919
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
page(s)
169-179
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Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
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3 January 2020
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Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes
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Global landscape of recent inferred Darwinian selection for Homo sapiens
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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response
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A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
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Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
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Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia
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Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia
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Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells
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Population history and natural selection shape patterns of genetic variation in 132 genes
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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
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Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.
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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
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A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations
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Signatures of natural selection in the human genome
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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
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Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.
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30 October 2018
Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
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Worldwide genetic variation at the 3'-UTR region of the LDLR gene: possible influence of natural selection
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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
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based on heuristic
inferred from PubMed ID database lookup
The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population
1 reference
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based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1097/FPC.0B013E3282F44D99
1 reference
stated in
Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
PMC publication ID
2842919
1 reference
stated in
Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
PubMed publication ID
18300938
1 reference
stated in
Europe PubMed Central
PMC publication ID
2842919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18300938%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 January 2020
ResearchGate publication ID
5551356
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