(Q33762518)

29 July 2017

Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses (English)

1 reference

29 July 2017

3

Jonathan S Dordick

1 reference

29 July 2017

Moo-Yeal Lee

1

1 reference

29 July 2017

Chan Beum Park

series ordinal

2

1 reference

29 July 2017

Douglas S Clark

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

18 January 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

1 reference

29 July 2017

102

1 reference

29 July 2017

983-987

1 reference

29 July 2017

4

1 reference

Phase I and II enzyme characterization of two sources of HepG2 cell lines

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Cytochrome P450 and liver diseases

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

57 varieties: the human cytochromes P450.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Acetaminophen-induced hepatotoxicity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

A new hepatoma cell line for toxicity testing at repeated doses

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Role of ADME characteristics in drug discovery and their in silico evaluation: in silico screening of chemicals for their metabolic stability

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Hit and lead generation: beyond high-throughput screening

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Combinatorial compound libraries for drug discovery: an ongoing challenge

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Bcl-2/bcl-xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin, paclitaxel and cyclophosphamide

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Clinical proteomics: translating benchside promise into bedside reality

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Microarrays of cells expressing defined cDNAs

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Screening for human ADME/Tox drug properties in drug discovery

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

The xenobiotic inhibitor profile of cytochrome P4502C8.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Human-derived cell lines to study xenobiotic metabolism

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Protein-bound acrolein: potential markers for oxidative stress

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Will combinatorial chemistry deliver real medicines?

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545843

Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.

22 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

NADPH-cytochrome P-450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Reduction of toxic metabolite formation of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406755102

Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes

21 January 2018

1 reference

12 December 2020

Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism

1 reference

12 December 2020

A microfabricated array bioreactor for perfused 3D liver culture

1 reference

12 December 2020

Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin

1 reference

12 December 2020

Organic chemistry in drug discovery

1 reference

12 December 2020

Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes

1 reference

12 December 2020

High-performance liquid chromatographic determination of acrolein as a marker for cyclophosphamide bioactivation in human liver microsomes

1 reference

12 December 2020

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

1 reference

12 December 2020

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

1 reference

12 December 2020

Cyclophosphamide. Complete inhibition of murine leukemia L1210 in vivo by a Fenton oxidation product

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0406755102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference