(Q33763221)

29 July 2017

title

Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists (English)

1 reference

29 July 2017

5

Larry A Sklar

1 reference

29 July 2017

Alexandre Chigaev

1

1 reference

29 July 2017

Yang Wu

series ordinal

2

1 reference

29 July 2017

D Bart Williams

series ordinal

3

1 reference

29 July 2017

Yelena Smagley

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

3 December 2010

1 reference

Journal of Biological Chemistry

29 July 2017

published in

1 reference

29 July 2017

volume

286

1 reference

29 July 2017

issue

7

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29 July 2017

page(s)

5455-5463

1 reference

Multiple non-psychiatric effects of phenothiazines: A review

29 July 2017

cites work

1 reference

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Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study

28 July 2018

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Conformational mAb as a tool for integrin ligand discovery

28 July 2018

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Concurrent blockade of alpha4-integrin and CXCR4 in hematopoietic stem/progenitor cell mobilization

28 July 2018

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Application of RGD-containing peptides as imaging probes for alphavbeta3 expression

28 July 2018

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Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion

28 July 2018

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ANTI-ADHESION evolves to a promising therapeutic concept in oncology

28 July 2018

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Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease

28 July 2018

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The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans

28 July 2018

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Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin

28 July 2018

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Progressive multifocal leukoencephalopathy: lessons from AIDS and natalizumab.

28 July 2018

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Integrin structure, allostery, and bidirectional signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

How do stem cells find their way home?

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

28 July 2018

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Allosteric modulators: the new generation of receptor antagonist

28 July 2018

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Monoclonal antibodies as probes of integrin priming and activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

FRET detection of cellular alpha4-integrin conformational activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatm

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Therapeutic antagonists and conformational regulation of integrin function

28 July 2018

1 reference

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Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells

28 July 2018

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Alpha 4 integrin antagonists

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

28 July 2018

1 reference

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Effects of antipsychotic drugs on cytokine networks

28 July 2018

1 reference

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Cell adhesion molecules in the development and progression of malignant melanoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

A history of antipsychotic drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Expression and function of integrins on hematopoietic progenitor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Possible immunological effects of psychotropic medication

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Structure-activity relationships of phenothiazines in inhibiting lymphocyte motility as determined by a novel flow cytometric assay

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037658

Cellular and molecular basis of preferential metastasis of breast cancer to bone

28 July 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Thioridazine: resurrection as an antimicrobial agent?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Alpha4beta1 integrin affinity changes govern cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Flow cytometric analysis of ligand-receptor interactions and molecular assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162636

[Comparative action of promethazine, chlorpromazine and cortisone in mice receiving fatal doses of a bacterial endotoxin]

21 January 2018

1 reference

12 December 2020

[Therapeutic monoclonal antibodies: update on the risk of opportunistic infections]

1 reference

12 December 2020

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

1 reference

12 December 2020

Expression of P-selectin at low site density promotes selective attachment of eosinophils over neutrophils

1 reference

12 December 2020

The Relationship of Atypical Lymphocytes, Phenothiazines, and Schizophrenia

1 reference

12 December 2020

Dissociation of immunosuppression by chlorpromazine and trifluoperazine from pharmacologic activities as dopamine antagonists

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.162636

1 reference

29 July 2017

1 reference

29 July 2017

1 reference