(Q58057915)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement (English)

1 reference

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1 November 2019

1

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1 November 2019

Martin J. Humphries

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Stephanie J Barton

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Janet A Askari

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Paul A McEwan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Patrick A Buckley

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Susan E Craig

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

language of work or name

English

0 references

publication date

3 March 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

1 November 2019

published in

1 reference

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1 November 2019

volume

278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

issue

19

1 reference

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1 November 2019

page(s)

17028-17035

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Integrins: bidirectional, allosteric signaling machines

1 November 2019

cites work

1 reference

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In vivo functions of integrins: lessons from null mutations in mice

21 January 2018

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21 January 2018

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

21 January 2018

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Divalent cation regulation of the function of the leukocyte integrin LFA-1

21 January 2018

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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

21 January 2018

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Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand

21 January 2018

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The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

21 January 2018

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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

21 January 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

21 January 2018

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21 January 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

21 January 2018

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

21 January 2018

1 reference

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Two conformations of the integrin A-domain (I-domain): a pathway for activation?

21 January 2018

1 reference

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Integrin structure: new twists and turns in dynamic cell adhesion

21 January 2018

1 reference

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Integrin activation and structural rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Generation of a minimal alpha5beta1 integrin-Fc fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain

21 January 2018

1 reference

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21 January 2018

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Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain

21 January 2018

1 reference

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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Molecular Basis of Ligand Recognition by Integrin α5β1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Engineering and design of ligand-induced conformational change in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Coming to grips with integrin binding to ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Integrin activation takes shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Conformational regulation of integrin structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Probing chemical and conformational differences in the resting and active conformers of platelet integrin alpha(IIb)beta(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Will the real integrin please stand up?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Structure-function of the putative I-domain within the integrin beta 2 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3

21 January 2018

1 reference

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Integrin affinity modulation

21 January 2018

1 reference

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Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

21 January 2018

1 reference

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Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

21 January 2018

1 reference

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'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

Beta1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand-induced conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213139200

21 January 2018

Identifiers

DOI

10.1074/JBC.M213139200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615914%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference