(Q33766312)

29 July 2017

p53 suppresses structural chromosome instability after mitotic arrest in human cells (English)

1 reference

29 July 2017

W B Dalton

1

1 reference

29 July 2017

B Yu

series ordinal

2

1 reference

29 July 2017

V W Yang

series ordinal

3

1 reference

29 July 2017

language of work or name

English

0 references

publication date

11 January 2010

1 reference

29 July 2017

1 reference

29 July 2017

29

1 reference

29 July 2017

1929-1940

1 reference

29 July 2017

13

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2009.477

29 July 2017

0 references

cites work

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Chromosomal instability determines taxane response

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Targeting p53 for enhanced radio- and chemo-sensitivity.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Extra centrosomes and/or chromosomes prolong mitosis in human cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Examining the link between chromosomal instability and aneuploidy in human cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Human cancer cells commonly acquire DNA damage during mitotic arrest

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Cell-cycle progression without an intact microtuble cytoskeleton

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Limiting the proliferation of polyploid cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

p53 in health and disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Tetraploidy, aneuploidy and cancer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

One, two, three--p53, p63, p73 and chemosensitivity.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

p53 regulates mitochondrial respiration

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Apoptosis regulation in tetraploid cancer cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Securin is not required for chromosomal stability in human cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Triggering p53 after cytokinesis failure

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Inactivation of hCDC4 can cause chromosomal instability

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Live or let die: the cell's response to p53

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Chromosomal stability and the DNA double-stranded break connection

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Megabase chromatin domains involved in DNA double-strand breaks in vivo

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Chromosome pulverization in human binucleate cells following colcemid treatment

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Chromosome pulverization in micronuclei induced by tritiated thymidine

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Classification and relationships of induced chromosomal structual changes

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.

22 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

A p53-dependent mouse spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

A substantial proportion of microsatellite-unstable colon tumors carryTP53 mutations while not showing chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Chromatid-type aberrations following irradiation in G0 lymphocytes with heavy ions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848712

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

30 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

TP53mutations are associated with a particular pattern of genomic imbalances in breast carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Mitotic cell death by chromosome fragmentation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.477

Targeted inactivation of p53 in human cells does not result in aneuploidy

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.477

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference