(Q46396099)

21 December 2017

title

Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol (English)

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21 December 2017

author

Rolf Müller

4

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21 December 2017

author name string

Anne Kienitz

1

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21 December 2017

Celia Vogel

2

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21 December 2017

Ivonne Morales

3

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21 December 2017

Holger Bastians

5

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21 December 2017

language of work or name

English

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publication date

1 June 2005

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21 December 2017

published in

Oncogene

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21 December 2017

volume

24

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21 December 2017

issue

26

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21 December 2017

page(s)

4301-4310

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21 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208589

exact match

0 references

cites work

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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Mutations of mitotic checkpoint genes in human cancers

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Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase

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Inducing precocious anaphase in cultured mammalian cells

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The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

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Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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Aneuploidy precedes and segregates with chemical carcinogenesis

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

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7 January 2021

Fluorometric and colorimetric detection of caspase activity associated with apoptosis

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

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7 January 2021

Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer

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A rapid and simple method for the isolation of apoptotic DNA fragments.

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Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

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Microtubules as a target for anticancer drugs

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Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

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Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

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Genetic instabilities in human cancers

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

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7 January 2021

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

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7 January 2021

Mitotic forces control a cell-cycle checkpoint

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

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Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers

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Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis

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7 January 2021

Timing and checkpoints in the regulation of mitotic progression

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7 January 2021

Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

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7 January 2021

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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7 January 2021

The spindle checkpoint: structural insights into dynamic signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Splitting the chromosome: cutting the ties that bind sister chromatids

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7 January 2021

Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers

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7 January 2021

The anaphase-promoting complex: proteolysis in mitosis and beyond

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7 January 2021

Aneuploidy and cancer

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7 January 2021

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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7 January 2021

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

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7 January 2021

Genomic instability--the engine of tumorigenesis?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Kinetochore localization of spindle checkpoint proteins: who controls whom?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

The mitotic spindle checkpoint is a critical determinant for topoisomerase-based chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Regulation of APC-Cdc20 by the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208589

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208589

1 reference

21 December 2017

1 reference

21 December 2017