(Q47651868)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

review article

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title

Genomic instability--the engine of tumorigenesis? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1

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7 November 2019

3

Ian P M Tomlinson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Karl Heinimann

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

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publication date

1 September 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

published in

Nature Reviews Cancer

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7 November 2019

volume

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

701-708

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7 November 2019

issue

9

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https://scigraph.springernature.com/pub.10.1038/nrc1170

7 November 2019

exact match

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cites work

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The fundamental role of epigenetic events in cancer

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Genome maintenance mechanisms for preventing cancer

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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Significance of multiple mutations in cancer

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Genetic instability and darwinian selection in tumours

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Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis

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The role of chromosomal instability in tumor initiation

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A genetic model for colorectal tumorigenesis

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Toward an understanding of the molecular genetics of prostate cancer progression

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Hallmarks of cancer progression in Barrett's oesophagus

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The onset and extent of genomic instability in sporadic colorectal tumor progression

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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Hereditary colorectal cancer

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Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

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Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

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The mutation rate and cancer

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Mutations of mitotic checkpoint genes in human cancers

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Intestinal adenomas can develop with a stable karyotype and stable microsatellites

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Mutator phenotypes in human colorectal carcinoma cell lines

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How many mutations in a cancer?

31 March 2020

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Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

31 March 2020

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Prevalence of somatic alterations in the colorectal cancer cell genome

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Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients

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Surfing the p53 network

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The role of selection in progressive neoplastic transformation

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Cytogenetic and molecular approaches of polyploidization in colorectal adenocarcinomas

31 March 2020

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Proliferative activity of breast cancers increases in the course of genetic evolution as defined by cytogenetic analysis

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Mutations in normal breast tissue and breast tumours

31 March 2020

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The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

31 March 2020

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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

31 March 2020

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Mutations in the APC tumour suppressor gene cause chromosomal instability

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Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas

31 March 2020

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Adenoma prevalence and cancer risk in familial non-polyposis colorectal cancer

31 March 2020

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Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

31 March 2020

1 reference

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations

31 March 2020

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Cytogenetic aberrations in colorectal adenocarcinomas and their correlation with clinicopathologic features

31 March 2020

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Cytogenetic analysis of 52 colorectal carcinomas--non-random aberration pattern and correlation with pathologic parameters

31 March 2020

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Karyotypic characterization of colorectal adenocarcinomas

31 March 2020

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Clonal karyotypic abnormalities in colorectal adenomas: clues to the early genetic events in the adenoma-carcinoma sequence

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31 March 2020

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Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors.

31 March 2020

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Characterization of human adenomatous polyps of the colorectal bowel by means of DNA distribution patterns

31 March 2020

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Flow cytometric DNA ploidy in colorectal adenomas and family history of colorectal cancer

31 March 2020

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Loss of heterozygosity analysis: practically and conceptually flawed?

31 March 2020

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Genetic analysis of multiple synchronous lesions of the colon adenoma-carcinoma sequence

31 March 2020

1 reference

Defects in mismatch repair occur afterAPC mutations in the pathogenesis of sporadic colorectal tumours

31 March 2020

1 reference

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer

31 March 2020

1 reference

Novel germlineCDH1mutations in hereditary diffuse gastric cancer families

31 March 2020

1 reference

E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer

31 March 2020

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Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

31 March 2020

1 reference

Emergence of multidrug resistance in leukemia cells during chemotherapy: mechanisms and prevention

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Drug resistance and drug development in multiple myeloma

31 March 2020

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Mechanisms of drug resistance in chemotherapy for urogenital carcinoma

31 March 2020

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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

31 March 2020

1 reference

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

31 March 2020

1 reference

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

31 March 2020

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Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

31 March 2020

1 reference

Methylation pattern of different regions of theMLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer

31 March 2020

1 reference

Hypermethylation of the p16/CDKN2A/MTSI gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas

31 March 2020

1 reference

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers

31 March 2020

1 reference

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

31 March 2020

1 reference

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1170

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12951589%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference